[CAS NO. 52205-73-9] Estramustine phosphate sodium

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PRODUCTS SPECIFICATIONS [52205-73-9]

Catalog

SLK-S2441

Brand

Selleck

CAS

52205-73-9

DESCRIPTION [52205-73-9]

Overview

MDL	MFCD00866320
Molecular Weight	564.35
Molecular Formula	C23H30Cl2NNa2O6P
SMILES	C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC(N(CCCl)CCCl)=O)=CC4)(CC1)[H])[H])(CC[C@@H]2OP(=O)(O)O)[H].[Na]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.7720 mL	8.8598 mL	17.7195 mL
5 mM	0.3544 mL	1.7720 mL	3.5439 mL
10 mM	0.1772 mL	0.8860 mL	1.7720 mL
50 mM	0.0354 mL	0.1772 mL	0.3544 mL

Description

Estramustine phosphate sodium (EMP, Emcyt, Estracyt) is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects.

References

[1] Perry CM, et al. Drugs Aging. 1995 Jul;7(1):49-74.
[2] Stearns ME, et al. Cancer Res. 1985 Aug;45(8):3891-7.

Synonyms

Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt (1:2)

Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt

Estramustine phosphate sodium

Estracyt

Estramustine phosphate disodium

Emcyt

Estramustine phosphate disodium salt

Ro 21-8837/001