[CAS NO. 486-35-1] Daphnetin

Name: Daphnetin
Brand: Arctom Scientific
SKU: SLK-S2554

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PRODUCTS SPECIFICATIONS [486-35-1]

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Catalog

SLK-S2554

Brand

Selleck

CAS

486-35-1

DESCRIPTION [486-35-1]

Overview

MDL	MFCD00016977
Molecular Weight	178.14
Molecular Formula	C9H6O4
SMILES	OC1=C2C(=CC=C1O)C=CC(=O)O2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits , and PKC with of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.

Targets

EGFR ^[1]	PKA ^[1]	PKC ^[1]
7.67 μM	9.33 μM	25.01 μM

In vitro

Daphnetin strongly inhibits not only EGF receptor-catalyzed tyrosine phosphorylation of exogenous substrate but also PKA and PKC activities. Daphnetin inhibits MCF-7 estrogen-responsive human carcinoma cell line at 24-hour exposure with IC50 of 73 μM. Daphnetin reduces the level of cyclin D1 even at 50 μM. Daphnetin protects the cortical neurons against dexamethasone-induced reduction of cell viability in a dose-dependent manner. Daphnetin inhibits the activities of endogenous or recombinant TaPRK in a specific and dose-dependent manner. daphnetin causes a 50% inhibition (IC50) of 3H-hypoxanthine incorporation by Plasmodium falciparum at concentrations between 25 μM and 40 μM. Daphnetin inhibits the mitogenic signalling of ERK1/ERK2.

In vivo

Daphnetin at 140 mg/kg significantly decreases uterine weights by 39.5%. Two and 8 mg/kg administration of Daphnetin could improve the performance of stress mice in Morris water maze tests and forced swimming tests. Daphnetin significantly prolongs survival of P. yoelli-infected mice.

References

[1] Yang EB, et al. Biochem Biophys Res Commun, 1999, 260(3), 682-685.
[2] Jiménez-Orozco FA, et al. Eur J Pharmacol, 2011, 668(1-2), 35-41
[3] Liao MJ, et al. Fundam Clin Pharmacol, 2012.
[4] Kane K, et al. Biochem Cell Biol, 2012, 90(5), 657-666.
[5] Yang YZ, et al. Am J Trop Med Hyg, 1992, 46(1), 15-20.
[6] Finn GJ, et al. Biochem Pharmacol, 2004, 67(9), 1779-1788.

Synonyms

2H-1-Benzopyran-2-one, 7,8-dihydroxy-

Daphnetin

Coumarin, 7,8-dihydroxy-

7,8-Dihydroxy-2H-1-benzopyran-2-one

Daphnetol

7,8-Dihydroxycoumarin

Ruixiangsu

NSC 633563

7,8-Dihydroxy-2H-chromen-2-one