[CAS NO. 1062159-35-6] WAY-600
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PRODUCTS SPECIFICATIONS [1062159-35-6]
Catalog
SLK-S2689
Brand
Selleck
CAS
1062159-35-6
DESCRIPTION [1062159-35-6]
Overview
| MDL | MFCD22419019 |
|---|---|
| Molecular Weight | 494.59 |
| Molecular Formula | C28H30N8O |
| SMILES | N1(C2=C3C(N(C4CCN(CC5=CC=CN=C5)CC4)N=C3)=NC(C6=CC7=C(NC=C7)C=C6)=N2)CCOCC1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0219 mL | 10.1094 mL | 20.2188 mL |
| 5 mM | 0.4044 mL | 2.0219 mL | 4.0438 mL |
| 10 mM | 0.2022 mL | 1.0109 mL | 2.0219 mL |
| 50 mM | - | - | - |
Description
WAY-600 is a potent, ATP-competitive and selective inhibitor of with of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
Targets
| mTOR [1] |
| 9 nM |
In vitro
Immune-complex kinase assay shows mTORC2-specific substrate His6-AKT or the mTORC1 substrate His6-S6K is dose dependently inhibited by WAY-600. WAY-600 globally inhibits mTOR signaling and AKT function in cellular models dose dependently. WAY-600 profoundly inhibits cap-dependent and global protein synthesis in MDA361, human breast cancer cells. WAY-600 shows antiproliferative effects in various cancer cell lines involving G1 cell cycle arrest and selective apoptosis. WAY-600 down-regulate angiogenic factors, VEGF and HIF-1α, in U87MG, MDA361 and LNCap cells.
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