[CAS NO. 220904-83-6] GW5074

Name: GW5074
Brand: Arctom Scientific
SKU: SLK-S2872

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PRODUCTS SPECIFICATIONS [220904-83-6]

Distributor

Catalog

SLK-S2872

Brand

Selleck

CAS

220904-83-6

DESCRIPTION [220904-83-6]

Overview

MDL	MFCD09971042
Molecular Weight	520.94
Molecular Formula	C15H8Br2INO2
SMILES	C(=C1C=2C(NC1=O)=CC=C(I)C2)C3=CC(Br)=C(O)C(Br)=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9196 mL	9.5980 mL	19.1961 mL
5 mM	0.3839 mL	1.9196 mL	3.8392 mL
10 mM	0.1920 mL	0.9598 mL	1.9196 mL
50 mM	0.0384 mL	0.1920 mL	0.3839 mL

Description

GW5074 is a potent and selective inhibitor with of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted. GW5074 inhibits LK-induced .

Targets

C-Raf ^[1]
(Cell-free assay)

9 nM

In vitro

GW5074 is a potent and specific inhibitor of c-Raf with IC50 of 9 nM and has no effect of MKK6, MKK7, p38 MAP kinase and cdks in vitro. However, treatment of neuronal cultures with GW5074 permits accumulation of activating modifications on c-Raf and also B-Raf. The inhibition of LK-induced apoptosis by GW5074 in cerebellar granule neurons is not MEK-ERK-dependent. GW5074 delays down-regulation of Akt activity but inhibits apoptosis by an Akt-independent mechanism. GW5074 affects Ras, nuclear factor-kappa B and c-jun. GW5074 inhibits cell death caused by neurotoxins in granule cells and other neuronal types.

References

[1] Chin PC, et al. J Neurochem, 2004, 90(3), 595-608.
[2] Yue X, et al. Eur J Pharmacol, 2006, 540(1-3), 57-59.
[3] Lei Y, et al. Respir Res, 2008, 9(1), 71.

Synonyms

2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-

3-[(3,5-Dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one

GW 5074

3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one