[CAS NO. 51298-62-5] L-NAME HCl
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PRODUCTS SPECIFICATIONS [51298-62-5]
Catalog
SLK-S2877
Brand
Selleck
CAS
51298-62-5
DESCRIPTION [51298-62-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 269.69 |
| Molecular Formula | C7H15N5O4.HCl |
| SMILES | [C@H](CCCNC(NN(=O)=O)=N)(C(OC)=O)N.Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.7080 mL | 18.5398 mL | 37.0796 mL |
| 5 mM | 0.7416 mL | 3.7080 mL | 7.4159 mL |
| 10 mM | 0.3708 mL | 1.8540 mL | 3.7080 mL |
| 50 mM | 0.0742 mL | 0.3708 mL | 0.7416 mL |
Description
L-NAME HCl (NG-Nitroarginine methyl ester, N-Nitro-L-arginine methylester) is a nonselective inhibitor of for nNOS (bovine), eNOS (human), and iNOS (murine), with of 15 nM, 39 nM and 4.4 μM, respectively.
In vitro
NG-nitro-L-arginine methyl ester (L-NAME; at 0.1-100 mM) causes concentration-dependent inhibition of the Ca(+)-dependent endothelial NO synthase from porcine aortae. L-NAME causes an endothelium-dependent contraction and an inhibition of the endothelium-dependent relaxation induced by acetylcholine (ACh) in aortic rings. In another research, Viability of rMC-1 cells or BREC in 25 mM glucose is significantly less than at 5 mM glucose, and this cell death is inhibited by l-NAME in both cell types.
In vivo
L-NAME (0.03-300 mg kg-1, i.v.) induces a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. L-NAME (100 mg kg-1, i.v.) inhibits significantly the hypotensive responses to ACh and bradykinin. The increase in blood pressure and bradycardia produced by L-NAME is reversed by L-arginine (30-100 mg kg-1, i.v.) in a dose-dependent manner.
References
Synonyms
L-Ornithine, N5-[imino(nitroamino)methyl]-, methyl ester, hydrochloride (1:1)
L-Ornithine, N5-[imino(nitroamino)methyl]-, methyl ester, monohydrochloride
Nitroarginine methyl ester hydrochloride
NG-Nitroarginine methyl ester hydrochloride
L-NAME hydrochloride
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