[CAS NO. 504433-23-2] GW441756
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [504433-23-2]
Distributor
Catalog
SLK-S2891
Brand
Selleck
CAS
504433-23-2
DESCRIPTION [504433-23-2]
Overview
| MDL | MFCD17010281 |
|---|---|
| Molecular Weight | 275.3 |
| Molecular Formula | C17H13N3O |
| SMILES | O=C1/C(C2=NC=CC=C2N1)=C\C3=CN(C)C4=C3C=CC=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6324 mL | 18.1620 mL | 36.3240 mL |
| 5 mM | 0.7265 mL | 3.6324 mL | 7.2648 mL |
| 10 mM | 0.3632 mL | 1.8162 mL | 3.6324 mL |
| 50 mM | 0.0726 mL | 0.3632 mL | 0.7265 mL |
Description
GW441756 is a potent, selective inhibitor of with of 2 nM, with very little activity to c-Raf1 and CDK2. GW441756 produces a relevant increase of that leads to .
Targets
| TrkA [1] (Cell-free assay) |
| 2 nM |
In vitro
GW441756 can specifically block TrkA-induced cell death in a dose-dependent manner. GW441756 can block TrkA-mediated γH2AX productionand apoptosis in TrkA-overexpressing cells.
References
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.