[CAS NO. 122955-13-9]  XE991 dihydrochloride

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PRODUCTS SPECIFICATIONS [122955-13-9]

Catalog
SLK-S2967
Brand
Selleck
CAS
122955-13-9

DESCRIPTION [122955-13-9]

Overview

MDLMFCD09055426
Molecular Weight449.37
Molecular FormulaC26H22Cl2N2O
SMILESO=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.[H]Cl.[H]Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.2253 mL11.1267 mL22.2534 mL
5 mM0.4451 mL2.2253 mL4.4507 mL
10 mM0.2225 mL1.1127 mL2.2253 mL
50 mM0.0445 mL0.2225 mL0.4451 mL

Description

XE 991 (LS190926) dihydrochloride is a blocker of that potently inhibits KCNQ1 (Kv7.1), KCNQ2 (Kv7.2), KCNQ2 + KCNQ3 (Kv7.3) channel, and M-current with IC50 of 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively.

Targets

KCNQ2 + KCNQ3 channel [1]
(Cell-free assay)
KCNQ2 [1]
(Cell-free assay)
KCNQ1 [1]
(Cell-free assay)
M-current [1]
(Cell-free assay)
0.6 μM0.71 μM0.75 μM0.98 μM