[CAS NO. 135729-62-3] Palonosetron HCl

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PRODUCTS SPECIFICATIONS [135729-62-3]

Catalog

SLK-S3050

Brand

Selleck

CAS

135729-62-3

DESCRIPTION [135729-62-3]

Overview

MDL	MFCD07370072
Molecular Weight	332.87
Molecular Formula	C19H24N2O.HCl
SMILES	O=C1C2=C3[C@@](CN1[C@H]4C5CCN(C4)CC5)(CCCC3=CC=C2)[H].Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.0042 mL	15.0209 mL	30.0418 mL
5 mM	0.6008 mL	3.0042 mL	6.0084 mL
10 mM	0.3004 mL	1.5021 mL	3.0042 mL
50 mM	0.0601 mL	0.3004 mL	0.6008 mL

Description

Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Targets

5-HT3 ^[1]

In vitro

Palonosetron is a highly potent, selective, second-generation 5-HT3 receptor antagonist with a 5-HT3 receptor binding affinity that is ∼100-fold higher than other 5-HT3 receptor antagonists (pKi 10.5 compared with 8.91 for granisetron, 8.81 for tropisetron, 8.39 for ondansetron, 7.6 for dolasetron). Palonosetron also has an extended plasma elimination half-life of ∼40 h, significantly longer than others in its class (ondansetron, 4 h; tropisetron, 7.3 h; dolasetron, 7.5 h; ranisetron, 8.9 h).

References

[1] Wong EH, et al. Br J Pharmacol, 1995, 114(4), 851-859.
[2] Gralla R, et al. Ann Oncol, 2003, 14(10), 1570-1577.

Synonyms

1H-Benz[de]isoquinolin-1-one, 2-[(3S)-1-azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-, hydrochloride (1:1), (3aS)-

1H-Benz[de]isoquinolin-1-one, 2-(1-azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-, monohydrochloride, [S-(R*,R*)]-

1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-, monohydrochloride, (3aS)-

RS 25259-197

Palonosetron hydrochloride

Aloxi

Onicit