[CAS NO. 82248-59-7] Atomoxetine HCl

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PRODUCTS SPECIFICATIONS [82248-59-7]

Catalog

SLK-S3175

Brand

Selleck

CAS

82248-59-7

DESCRIPTION [82248-59-7]

Overview

MDL	MFCD06410992
Molecular Weight	291.82
Molecular Formula	C17H21NO.HCl
SMILES	[C@@H](OC1=C(C)C=CC=C1)(CCNC)C2=CC=CC=C2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.4268 mL	17.1338 mL	34.2677 mL
5 mM	0.6854 mL	3.4268 mL	6.8535 mL
10 mM	0.3427 mL	1.7134 mL	3.4268 mL
50 mM	0.0685 mL	0.3427 mL	0.6854 mL

Description

Atomoxetine (LY 139603) is a selective inhibitor with of 5 nM, with 15- and 290-fold lower affinity for human 5-HT and DA transporters.

Targets

Norepinephrine (NE) transporter ^[1]	5-HT ^[1]	DA transporter ^[1]
5 nM(Ki)	77 nM(Ki)	1451 nM(Ki)

In vitro

Atomoxetine is a selective norepinephrine reuptake inhibitor with K of 5 nM, compared with 77 and 1451 nM for binding to serotonin and dopamine transporters.

In vivo

In microdialysis studies, atomoxetine increases extracellular (EX) levels of NE in prefrontal cortex (PFC) 3-fold, but does not alter 5-HT levels. Atomoxetine also increases DA concentrations in PFC 3-fold, but does not alter DA in striatum or nucleus accumbens. Atomoxetine increases Fos by 3.7-fold in PFC, but not in the striatum or nucleus accumbens. Atomoxetine selectively inhibits the presynaptic uptake of norepinephrine in adrenergic neurons in animals, and has activity in animal models of depression.

References

[1] Bymaster FP, et al. Neuropsychopharmacology, 2002, 27(5), 699-711.
[2] Zerbe RL, et al. J Pharmacol Exp Ther, 1985, 232(1), 139-143.
[3] Wong DT, et al. J Pharmacol Exp Ther, 1982, 222(1), 61-65.

Synonyms

Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, hydrochloride (1:1), (γR)-

Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, hydrochloride, (R)-

Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, hydrochloride, (γR)-

LY 139603

Tomoxetine hydrochloride

(R)-(-)-Tomoxetine hydrochloride

(R)-Tomoxetine hydrochloride

Atomoxetine hydrochloride

(R)-(-)-N-Methyl-3-[(2-methylphenyl)oxy]-3-phenyl-1-aminopropane hydrochloride

Strattera

(R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine hydrochloride

Atemoxetine hydrochloride

(R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine hydrochloride