[CAS NO. 892546-37-1]  PH-064

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PRODUCTS SPECIFICATIONS [892546-37-1]

Catalog
SLK-S3451
Brand
Selleck
CAS
892546-37-1

DESCRIPTION [892546-37-1]

Overview

MDL-
Molecular Weight795.11
Molecular FormulaC44H58N8O2S2
SMILESO=C([C@H](CSSC[C@@H](C(N1CCN2C([C@@H]1CC3CCCCC3)=NC(C4=CC=CC=C4)=C2)=O)N)N)N([C@H]5CC6CCCCC6)CCN(C5=N7)C=C7C8=CC=CC=C8

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.2577 mL6.2884 mL12.5769 mL
5 mM0.2515 mL1.2577 mL2.5154 mL
10 mM0.1258 mL0.6288 mL1.2577 mL
50 mM0.0252 mL0.1258 mL0.2515 mL

Description

PH-064 (BIM-46187) is a novel imidazo-pyrazine derivative that inhibits the heterotrimeric G-protein complex effectively. PH-064 (BIM46174) inhibits that mediate cyclic AMP generation (GAs), calcium release (GAq), cancer cell invasion by , and high-affinity neurotensin receptors .

Targets

Gα12/13 [1]Gαq/11 [1]Gα0 [3]
(BRET Measurements)
Gαi1 [3]
(BRET Measurements)
0.0043 nM0.0047 nM