[CAS NO. 1558598-41-6] PFM01
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PRODUCTS SPECIFICATIONS [1558598-41-6]
Catalog
SLK-S3549
Brand
Selleck
CAS
1558598-41-6
DESCRIPTION [1558598-41-6]
Overview
| MDL | MFCD02220972 |
|---|---|
| Molecular Weight | 293.40 |
| Molecular Formula | C14H15NO2S2 |
| SMILES | O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.4083 mL | 17.0416 mL | 34.0832 mL |
| 5 mM | 0.6817 mL | 3.4083 mL | 6.8166 mL |
| 10 mM | 0.3408 mL | 1.7042 mL | 3.4083 mL |
| 50 mM | 0.0682 mL | 0.3408 mL | 0.6817 mL |
Description
PFM01, a cell-permeable N-alkylated Mirin derivative, is a selective inhibitor of endonuclease activity.
Targets
| MRE11 [1] |
In vitro
PFM01 rescues the repair defect in 48BR (WT) and HSC62 (BRCA2-defective) primary cells, diminishes the RAD51 foci formation in 1BR3 (WT) and HSC62 (BRCA2-defective) cells, enhances non-homologous end-joining (NHEJ) in H1299 dA3 cells and reduces homologous recombination (HR) in U2OS DR-GFP cells, also substantially relieves the double-strand break (DSB) repair defect confers by mirin or PFM39 in irradiated G2 cells.
References
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