[CAS NO. 334-50-9] Spermidine trihydrochloride

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PRODUCTS SPECIFICATIONS [334-50-9]

Catalog

SLK-S3653

Brand

Selleck

CAS

334-50-9

DESCRIPTION [334-50-9]

Overview

MDL	MFCD00012918
Molecular Weight	254.63
Molecular Formula	C7H19N3.3HCl
SMILES	C(NCCCN)CCCN.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.9273 mL	19.6363 mL	39.2727 mL
5 mM	0.7855 mL	3.9273 mL	7.8545 mL
10 mM	0.3927 mL	1.9636 mL	3.9273 mL
50 mM	0.0785 mL	0.3927 mL	0.7855 mL

Description

Spermidine (4-Azaoctamethylenediamine), a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel inducer and negatively modulates .

Targets

Autophagy ^[1]

NMDAR ^[1]

In vitro

Spermidine induces autophagy in cultured yeast and mammalian cells, as well as in nematodes and flies.

In vivo

Spermidine at 200 μg/mouse, intracerebellar injection (icb), does not alter basal cGMP levels. Spermidine attenuates responses mediated through the N-methyl-D-aspartate (NMDA), NMDA-associated glycine receptor and quisqualate receptors. Spermidine is widely distributed in neural and non-neural tissues and has been shown to play a key role in cell differentiation and growth.

References

[1] Madeo F, et al. Autophagy. 2010, 6(1):160-2.
[2] Rao TS, et al. Neurochem Int. 1990, 16(2):199-206.

Synonyms

1,4-Butanediamine, N¹-(3-aminopropyl)-, hydrochloride (1:3)

1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride

Spermidine trihydrochloride

Spermidine hydrochloride