[CAS NO. 134418-28-3] Dehydroandrographolide

Name: Dehydroandrographolide
Brand: Arctom Scientific
SKU: SLK-S3807

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PRODUCTS SPECIFICATIONS [134418-28-3]

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Catalog

SLK-S3807

Brand

Selleck

CAS

134418-28-3

DESCRIPTION [134418-28-3]

Overview

MDL	MFCD03093712
Molecular Weight	332.43
Molecular Formula	C20H28O4
SMILES	C[C@]12[C@@]([C@@](CO)(C)[C@H](O)CC1)(CCC(=C)[C@@H]2C/C=C\3/C(=O)OC=C3)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.0082 mL	15.0408 mL	30.0815 mL
5 mM	0.6016 mL	3.0082 mL	6.0163 mL
10 mM	0.3008 mL	1.5041 mL	3.0082 mL
50 mM	0.0602 mL	0.3008 mL	0.6016 mL

Description

Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.

Targets

TMEM16A ^[1]

In vitro

Dehydroandrographolide inhibits TMEM16A chloride currents in Fisher rat thyroid (FRT) cells that are transfected stably with human TMEM16A and in TMEM16A-overexpressed SW620 cells but does not alter cystic fibrosis transmembrane conductance regulator (CFTR) chloride currents. Further functional studies show that dehydroandrographolide suppresses the proliferation of SW620 cells in a dose- and time-dependent manner using MTT assays. Dehydroandrographolide significantly inhibits migration and invasion of SW620 cells as detected by wound-healing and transwell assays. Moreover, treatment of SW620 cells with dehydroandrographolide leads to a decrease in TMEM16A protein levels but has no effect on TMEM16A mRNA levels. Dehydroandrographolide induces autophagy in human oral cancer cells by modulating p53 expression, activating JNK1/2, and inhibiting Akt and p38. Dehydroandrographolide is an iNOS inhibitor and an antiinflammatory and antiviral agent.

In vivo

Administration of dehydroandrographolide effectively suppresses the tumor formation in the oral carcinoma xenograft model in vivo.

References

[1] Yujie Sui, et al. PLoS One. 2015, 10(12): e0144715.
[2] Hsieh MJv, et al. Oncotarget. 2015, 6(31):30831-49.

Synonyms

2(3H)-Furanone, 3-[2-[(1S,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, (3E)-

2(3H)-Furanone, 3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-, [1R-[1α,2α,4aα,5β(E),8aβ]]-

(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]-2(3H)-furanone

Dehydroandrographolide