[CAS NO. 18524-94-2] Loganin

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [18524-94-2]

Catalog

SLK-S3835

Brand

Selleck

CAS

18524-94-2

DESCRIPTION [18524-94-2]

Overview

MDL	MFCD00075645
Molecular Weight	390.38
Molecular Formula	C17H26O10
SMILES	O([C@H]1[C@]2([C@@](C(C(OC)=O)=CO1)(C[C@H](O)[C@@H]2C)[H])[H])[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5616 mL	12.8080 mL	25.6161 mL
5 mM	0.5123 mL	2.5616 mL	5.1232 mL
10 mM	0.2562 mL	1.2808 mL	2.5616 mL
50 mM	0.0512 mL	0.2562 mL	0.5123 mL

Description

Loganin (Loganoside) is an iridoid glycoside first isolated from the seeds of Strychnos nux-vomica, a member of the Loganiaceae family. It is a non-competitive inhibitor of with IC50 of 47.97 μM an also inhibits and with IC50 values of 3.95 μM and 33.02 μM, respectively.

Targets

AChE ^[1] (Cell-free assay)	BChE ^[1] (Cell-free assay)	BACE1 ^[1] (Cell-free assay)
3.95 μM	33.02 μM	47.97 μM

In vitro

In SMN-deficient NSC34 cells, loganin increases cell viability, neurite length, and expressions of SMN, Gemin2, SMN-Gemin2 complex, p-Akt, p-GSK-3, p-CREB, BDNF and Bcl-2. Loganin attenuates H2O2-induced neuronal damage via suppressing MAPKs signals in SH-SY5Y cells. Loganin may directly promote the differentiation and inhibit the apoptosis of MC3T3-E1 cells and indirectly reduce bone resorption. Loganin could directly enhance the function of osteoblasts and elevate their survival rate, indirectly inhibit the function of osteoclastd and reduce the number of osteoclastd via RANKL from osteoblastd.

In vivo

Loganin provides benefits to SMA (pinal muscular atrophy) therapeutics via improving SMN (survival motor neuron) restoration, muscle strength and body weight. In type 2 diabetes mice, loganin not only lowers blood glucose but also attenuates hyperglycemia-induced inflammation, oxidative stress and apoptosis. Loganin improves spatial memory in streptozotocin-induced diabetic rats and exhibits antiamnesic activity in scopolamine-treated mice via acetylcholinesterase inhibition.

References

[1] Bhakta HK, et al. Arch Pharm Res. 2016, 39(6):794-805.
[2] Tseng YT, et al. Pharmacol Res. 2016, 111:58-75.
[3] Li M, et al. Molecules. 2010, 15(10):7403-14.

Synonyms

Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, methyl ester, (1S,4aS,6S,7R,7aS)-

Loganin

Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, methyl ester, [1S-(1α,4aα,6α,7α,7aα)]-

Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methyl-, methyl ester

(1S)-1α-(β-D-Glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-6α-hydroxy-7α-methylcyclopenta[c]pyran-4-carboxylic acid methyl ester

7-Hydroxy-6-desoxyverbenalin

Loganoside

(-)-Loganin

NSC 606403