Welcome to Arctom, sign up to enjoy up to 20% OFF

Search in Small Molecules Search in Biologics

Structure Search

Cart - 0 item(s)
$0.00

Your shopping cart is empty!

Chemistry
Bioactive Molecules
Natural Products
ADCs
Antibodies
- Primary Antibodies
- Secondary Antibodies
Multiplex IHC
Material Science
Others

[CAS NO. 19130-96-2] 1-Deoxynojirimycin

Ships within

Stock

Price

Qty

Total

SDS

COA

Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.

Catalog:	SLK-S3839
Brand:	Selleck
CAS:	19130-96-2

Overview

MDL	MFCD00063474
Molecular Weight	163.17
Molecular Formula	C6H13NO4
SMILES	C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	6.1286 mL	30.6429 mL	61.2858 mL
5 mM	1.2257 mL	6.1286 mL	12.2572 mL
10 mM	0.6129 mL	3.0643 mL	6.1286 mL
50 mM	0.1226 mL	0.6129 mL	1.2257 mL

Description

1-Deoxynojirimycin (duvoglustat, moranolin) is a potent inhibitor and most commonly found in mulberry leaves. It has therapeutic potency against diabetes mellitus.

Targets

α-glucosidase ^[3]
(Cell-free assay)

In vitro

1-Deoxynojirimycin (DNJ) up to 200 μmol/L does not influence survival of HUVECs. DNJ behaves as an antioxidant, decreases ROS production, and delays cellular senescence.

In vivo

1-Deoxynojirimycin (DNJ) inhibits intestinal glucose absorption in intestine. 1-Deoxynojirimycin down-regulates intestinal SGLT1, Na+/K+-ATP and GLUT2 mRNA and protein expression. Pretreatment with DNJ (50 mg/kg) increases the activity, mRNA and protein levels of hepatic glycolysis enzymes (GK, PFK, PK, PDE1) and decreases the expression of gluconeogenesis enzymes (PEPCK, G-6-Pase), improves glucose tolerance in both normal and diabetic mice. DNJ inhibits intestinal glucose absorption and accelerates hepatic glucose metabolism by directly regulating the expression of proteins involved in glucose transport systems, glycolysis and gluconeogenesis enzymes. DNJ reduces oxidative stress in the liver and plasma in rodents.

References

[1] Li YG, et al. Sci Rep. 2013, 3:1377.
[2] E S, et al. Exp Gerontol. 2014, 55:63-9.
[3] Papandréou MJ, et al. Mol Pharmacol. 2002, 61(1):186-93.

Synonyms

3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-

Glucopyranose, 5-amino-1,5-dideoxy-, D-

3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, [2R-(2α,3β,4α,5β)]-

(2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol

Nojirimycin, 1-deoxy-

1-Deoxynojirimycin

D-Glucitol, 1,5-dideoxy-1,5-imino-

Moranoline

5-Amino-1,5-dideoxy-D-glucopyranose

Moranolin

Deoxynojirimycin

BAY-h 5595

1,5-Dideoxy-1,5-imino-D-glucitol

D-1-Deoxynojirimycin

Duvoglustat

Request a Quote

Please fill in your details below to request a COA for our product. We will send the COA to the provided email address promptly.

Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.

Information

Shipping
Privacy notice
Terms of Service
About us
Contact us

Customer service

Search
Custom Synthesis

My account

My account
Orders
Addresses
Shopping cart