[CAS NO. 491-54-3] Kaempferide

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PRODUCTS SPECIFICATIONS [491-54-3]

Catalog

SLK-S3879

Brand

Selleck

CAS

491-54-3

DESCRIPTION [491-54-3]

Overview

MDL	MFCD00016771
Molecular Weight	300.26
Molecular Formula	C16H12O6
SMILES	O=C1C=2C(OC(=C1O)C3=CC=C(OC)C=C3)=CC(O)=CC2O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.3304 mL	16.6522 mL	33.3045 mL
5 mM	0.6661 mL	3.3304 mL	6.6609 mL
10 mM	0.3330 mL	1.6652 mL	3.3304 mL
50 mM	0.0666 mL	0.3330 mL	0.6661 mL

Description

Kaempferide (4'-Methylkaempferol, 4'-O-Methylkaempferol, Kaempferol 4'-methyl ether), a natural compound derived from the roots of kaempferia galanga, has a variety of effects including anti-carcinogenic, anti-inflammatory, anti-oxidant, anti-bacterial and anti-viral properties.

In vitro

Kaempferide is able to induce apoptosis in the "side population" (SP, a subpopulation enriched with CSC in various cancers) cells in myeloma. It reverses the activity of drug efflux transporter. Kaempferide is non-toxic to normal fibroblasts while inducing morphological changes, membrane flip-flop and nuclear membrane damage, characteristic of apoptosis in HeLa cells. It is highly cytotoxic to cervical cancer cells. Kaempferide-induced cytotoxicity is independent of cell cycle arrest.

In vivo

Kaempferide (Kae) remarkably improves cardiac function, alleviates myocardial injury via a decrease in myocardial enzyme levels, and attenuates myocardial infarct size in a dose-dependent manner. It attenuates I/R-induced myocardial injury through inhibition of the Nrf2 and cleaved caspase-3 signaling pathways via a PI3K/Akt/GSK 3β-dependent mechanism. Preconditioning treatment with Kae significantly decreases serum TNF-α, IL-6, C-reactive protein (CRP), MDA, and ROS levels, while increases serum levels of SOD. Nuclear factor erythroid 2-related factor 2 (Nrf2) and cleaved caspase-3 expression levels are downregulated, while phospho-Akt (p-Akt) and phospho-glycogen synthase kinase-3β (p-GSK-3β) expression levels are upregulated. Kaempferide is non-toxic as assessed by acute and chronic toxicity studies in Swiss albino mice in vivo.

References

[1] Dong Wang, et al. Mediators of Inflammation. 2017, 5278218.
[2] YS Loh, et al. Blood. 2010, 116: 5029.
[3] Lekshmi R. Nath, et al. RSC Adv. 2015, 5: 100912-100922.

Synonyms

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-

Kaempferide

Flavone, 3,5,7-trihydroxy-4′-methoxy-

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

3,5,7-Trihydroxy-4′-methoxyflavone

Kaempferol 4′-methyl ether

Kaempferid

4′-O-Methylkaempferol

4′-Methylkaempferol

4′-Methoxykaempferol

5,7-Dihydroxy-4′-methoxyflavonol

NSC 407294

Kaempferol 4′-O-methyl ether

Kaempherol 4′-O-methyl ether

4′-O-Methylkaempherol

3,5,7-Trihydroxy-2-(4-methoxyphenyl)chromen-4-one

3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one