[CAS NO. 22255-22-7] 3,4',5-Trimethoxy-trans-stilbene

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PRODUCTS SPECIFICATIONS [22255-22-7]

Catalog

SLK-S3888

Brand

Selleck

CAS

22255-22-7

DESCRIPTION [22255-22-7]

Overview

MDL	MFCD02093500
Molecular Weight	270.32
Molecular Formula	C17H18O3
SMILES	C(=C/C1=CC=C(OC)C=C1)\C2=CC(OC)=CC(OC)=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.6993 mL	18.4966 mL	36.9932 mL
5 mM	0.7399 mL	3.6993 mL	7.3986 mL
10 mM	0.3699 mL	1.8497 mL	3.6993 mL
50 mM	0.0740 mL	0.3699 mL	0.7399 mL

Description

3,4',5-Trimethoxy-trans-stilbene (MR-3) is a methylated derivative of resveratrol and shows more potent inhibitory effects on the growth of human cancer cells (HT-29, PC-3, COLO 205) with IC50 values of 81.31, 42.71 and 6.25 μM, respectively.

In vitro

Treatment with MR-3 at different concentrations ranging from 0 to 10 μM exhibits no cytotoxic effects on the A549 cells. MR-3 inhibits adhesion, migration, and invasion of A549 cells. The anti-invasive effects of MR-3 on A549 cells are likely mediated through the inhibition of phosphorylation of JNK and p38, as well as a reduction in the protein levels of nuclear factorkappa B (NF-kB) and activator protein-1 (AP-1) in the nucleus, ultimately leading to downregulation of MMP-2 expression.

References

[1] Yang YT, et al. Mol Nutr Food Res. 2009, 53(3):407-16.

Synonyms

Benzene, 1,3-dimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-

Stilbene, 3,4′,5-trimethoxy-, (E)-

Benzene, 1,3-dimethoxy-5-[2-(4-methoxyphenyl)ethenyl]-, (E)-

1,3-Dimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]benzene

3,4′,5-Trimethoxy-trans-stilbene

Resveratrol trimethyl ether

Tri-O-methylresveratrol

(E)-3,5,4′-Trimethoxystilbene

3,5,4′-Trimethoxy-trans-stilbene

(E)-1-(4-Methoxyphenyl)-2-(3,5-dimethoxyphenyl)ethene

(E)-2-(3,5-Dimethoxyphenyl)-1-(4-methoxyphenyl)ethene

(E)-1,3-Dimethoxy-5-(4-methoxystyryl)benzene

(E)-3,4′,5-Trimethoxystilbene

trans-Trimethoxyresveratrol

BTM 0512