[CAS NO. 480-39-7] Pinocembrin

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PRODUCTS SPECIFICATIONS [480-39-7]

Catalog

SLK-S3941

Brand

Selleck

CAS

480-39-7

DESCRIPTION [480-39-7]

Overview

MDL	MFCD06858345
Molecular Weight	256.25
Molecular Formula	C15H12O4
SMILES	O=C1C=2C(O[C@@H](C1)C3=CC=CC=C3)=CC(O)=CC2O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.9024 mL	19.5122 mL	39.0244 mL
5 mM	0.7805 mL	3.9024 mL	7.8049 mL
10 mM	0.3902 mL	1.9512 mL	3.9024 mL
50 mM	0.0780 mL	0.3902 mL	0.7805 mL

Description

Pinocembrin (Dihydrochrysin, Galangin flavanone, 5,7-Dihydroxyflavanone) is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities.

In vitro

Pinocembrin (5,7-dihydroxyflavanone) is one of the primary flavonoids isolated from the variety of plants, mainly from Pinus heartwood, Eucalyptus, Populus, Euphorbia, and Sparattosperma leucanthum, in the diverse flora and purified by various chromatographic techniques. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. Pinocembrin has been shown to increase neuronal viability, decrease lactate dehydrogenase release, inhibit the production of NO and ROS, increase glutathione levels, and downregulate the expression of neuronal NO synthase (nNOS) and iNOS in primary cortical neurons subjected to oxygen-glucose deprivation/reoxygenation (OGD/R).

In vivo

Pinocembrin can be used as neuroprotective against cerebral ischemic injury with a wide therapeutic time window, which may be attributed to its antiexcitotoxic effects. It has the ability to reduce reactive oxygen species (ROS), protect the BBB, modulate mitochondrial function, and regulate apoptosis. Pinocembrin (10 mg/kg, i.v.) could reduce brain swelling; improve behavioral deficits; and alleviate neuronal apoptosis, edema of astrocytic end-feet, and the deformation of endothelial cells and capillaries. Pinocembrin reduces endoplasmic reticulum (ER) stress and apoptosis by decreasing C/EBP homologous protein (CHOP)/GADD153 and caspase-12 expression via the PERK-elF2α-ATF4 signaling pathway in MCAO rats. LD50 of i.v. pinocembrin in mice is greater than 700 mg/kg.

References

[1] Rasul A, et al. Biomed Res Int. 2013, 2013:379850.
[2] Lan X, et al. Mol Neurobiol. 2016, 53(3):1794-1801.
[3] Yang Z, et al. J Pharm Biomed Anal. 2009, 49(5):1277-81.
[4] Izuta H, et al. J Agric Food Chem. 2008, 56(19):8944-53.

Synonyms

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (2S)-

Pinocembrin

4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-phenyl-, (S)-

(2S)-2,3-Dihydro-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one

Galangin flavanone

Dihydrochrysin

5,7-Dihydroxyflavanone

NSC 279005

(+)-Pinocembrin

(+)-Pinocoembrin

(2S)-Pinocembrin

(2S)-5,7-Dihydroxy-2-phenyl-2,3-dihydrochromen-4-one