[CAS NO. 11042-64-1] Gamma-Oryzanol
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [11042-64-1]
Store
Catalog
SLK-S3957
Brand
Selleck
CAS
11042-64-1
DESCRIPTION [11042-64-1]
Overview
| MDL | MFCD00867548 |
|---|---|
| Molecular Weight | 602.89 |
| Molecular Formula | C40H58O4 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6587 mL | 8.2934 mL | 16.5868 mL |
| 5 mM | 0.3317 mL | 1.6587 mL | 3.3174 mL |
| 10 mM | 0.1659 mL | 0.8293 mL | 1.6587 mL |
| 50 mM | 0.0332 mL | 0.1659 mL | 0.3317 mL |
Description
Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).
In vitro
From the proliferation assay using MTT reagent, the effect of gamma-oryzanol on DU145 and PC3 are slightly different with an IC50 after 7 days of exposure at 0.52±0.06 and 0.40±0.08 mg/ml, respectively. For in vitro condition in proliferation assay, IC50 values seem to be high in the scale of mg/ml. gamma-oryzanol may affect to prostate cancer cells through the down regulation of some antioxidant genes, CAT and GPX.
In vivo
In tumor-bearing mice, gamma-oryzanol can reduce tumor mass associated with pro-angiogenic biomarkers. Gamma-oryzanol is not carcinogenic and are safe for animals. In vivo trials proved gamma-oryzanol to be powerful antioxidant and also appears to be a very promising anticancerogenic compound. Supplementation of gamma-oryzanol in diabetic patients may improve metabolic dysfunctions such as hyperglycaemia, hypercholesterolaemia, hypertriglyceridaemia, insulin resistance and may alleviate diabetic complications resulting from lipid peroxidation and free radicals.
References
Synonyms
γ-Oryzanol
OZ
γ-OZ
γ-Orizanol
Hi-Z
Caclate
Oryvita
Gammajust 50
Oliver
Oryzaal
Gammatsul
Guntrin
Gamma-OZ
Maspiron
Thiaminogen
gamma-Orizanol
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.