[CAS NO. 554-57-4] Methazolamide

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PRODUCTS SPECIFICATIONS [554-57-4]

Catalog

SLK-S4039

Brand

Selleck

CAS

554-57-4

DESCRIPTION [554-57-4]

Overview

MDL	MFCD00083416
Molecular Weight	236.27
Molecular Formula	C5H8N4O3S2
SMILES	N(C(C)=O)=C1SC(S(N)(=O)=O)=NN1C

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.2324 mL	21.1622 mL	42.3245 mL
5 mM	0.8465 mL	4.2324 mL	8.4649 mL
10 mM	0.4232 mL	2.1162 mL	4.2324 mL
50 mM	0.0846 mL	0.4232 mL	0.8465 mL

Description

Methazolamide (CL 8490) is a inhibitor with of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

Features

Methazolamide potently inhibits various isoforms of carbonic anhydrase.

Targets

hCAII ^[1]	bCAIV ^[1]	hCAI ^[1]
14 nM(Ki)	36 nM(Ki)	50 nM(Ki)

In vitro

Methazolamide is a carbonic anhydrase inhibitor with K of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca-dependent potassium channels in skeletal muscles.

In vivo

Methazolamide does not impair respiratory work performance in anesthetized rabbits.

References

[1] Casini A, et al. Bioorg Med Chem Lett, 2003, 13(5), 841-845.
[2] Kiwull-Sch?ne HF, et al. Am J Physiol Regul Integr Comp Physiol, 2009, 297(3), R648-654.
[3] Pocker Y, et al. Biochemistry, 1967, 6(3), 668-678.

Synonyms

Acetamide, N-[5-(aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]-

Acetamide, N-(4-methyl-2-sulfamoyl-Δ²-1,3,4-thiadiazolin-5-ylidene)-

N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide

5-Acetylimino-4-methyl-Δ²-1,3,4-thiadiazoline-2-sulfonamide

Methazolamide

Methenamide

N-(4-Methyl-2-sulfamoyl-Δ²-1,3,4-thiadiazolin-5-ylidene)acetamide

Neptazane

Neptazaneat

L 584601