[CAS NO. 7177-50-6] Nafcillin Sodium

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Catalog:	SLK-S4042
Brand:	Selleck
CAS:	7177-50-6

Overview

MDL	-
Molecular Weight	454.47
Molecular Formula	C21H21N2O5S.H2O.Na
SMILES	C(O)(=O)[C@@H]1N2[C@@]([C@H](NC(=O)C=3C4=C(C=CC3OCC)C=CC=C4)C2=O)(SC1(C)C)[H].[Na].O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2004 mL	11.0018 mL	22.0037 mL
5 mM	0.4401 mL	2.2004 mL	4.4007 mL
10 mM	0.2200 mL	1.1002 mL	2.2004 mL
50 mM	0.0440 mL	0.2200 mL	0.4401 mL

Description

Nafcillin sodium (CL 8491) reversibly inhibits with of 33 mM.

Targets

β-lactamase ^[1]

33 mM(Kd)

In vitro

Nafcillin sodium inactivates β-lactamase through forming a covalent acyl-enzyme intermediate with β-lactamase via Ser-70. At concentrations above 80 mM, Nafcillin displays complete inhibition of β-lactamase within 200 s. Upon removal of the excess Nafcillin, the inhibited enzyme can be re-activated completely, with a rate constant of 2×10/s (25 ℃). Nafcillin sodium is activity against penicillin-resistant staphylococci. The minimal concentration necessary for antistaphylococcic activity in vitro ranges from 0.2 μg/mL to 2 μg/mL.

References

[1] Tan AK, et al. Biochem J, 1992, 281 ( Pt 1), 191-196.
[2] Schwichtenberg AH. JAMA, 1965, 191:930-931.

Synonyms

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt, hydrate (1:1:1), (2S,5R,6R)-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, [2S-(2α,5α,6β)]-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, monohydrate, (2S,5R,6R)-

Sodium nafcillin monohydrate

Sodium 6-(2-ethoxy-1-naphthamido)penicillanate monohydrate

Nafcillin sodium hydrate

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