[CAS NO. 22232-54-8] Carbimazole

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [22232-54-8]

Catalog

SLK-S4048

Brand

Selleck

CAS

22232-54-8

DESCRIPTION [22232-54-8]

Overview

MDL	MFCD00027421
Molecular Weight	186.23
Molecular Formula	C7H10N2O2S
SMILES	C(OCC)(=O)N1C(=S)N(C)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	5.3697 mL	26.8485 mL	53.6970 mL
5 mM	1.0739 mL	5.3697 mL	10.7394 mL
10 mM	0.5370 mL	2.6849 mL	5.3697 mL
50 mM	0.1074 mL	0.5370 mL	1.0739 mL

Description

Carbimazole is an imidazole antithyroid agent.

In vitro

Carbimazole is an effective thyroid hormone inhibitor under a class of drugs known as pro-drugs. It is considered a pro-drug because it converts to methimazole after being absorbed by the body, generating an antithyroid action that works against hyperthyroidism (excessive production of thyroid hormones) and thyrotoxicosis (inflammation of the thyroid gland). Methimazole prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).

References

[1] Taurog A, et al. Endocrinology, 1976, 98(4), 1031-1046.
[2] Magnusson RP, et al. J Biol Chem, 1984, 259(1), 197-205.

Synonyms

1H-Imidazole-1-carboxylic acid, 2,3-dihydro-3-methyl-2-thioxo-, ethyl ester

4-Imidazoline-1-carboxylic acid, 3-methyl-2-thioxo-, ethyl ester

Tyrazol

Carbimazole

1-Ethoxycarbonyl-3-methyl-2-thio-4-imidazoline

Ethyl 3-methyl-2-thioimidazoline-1-carboxylate

1-Methyl-3-carbethoxy-2-thioglyoxalone

Athyromazole

CG 1

3-Carbethoxymercapto-1-methylimidazole

Carbethoxymethimazole

3-Carbethoxythio-1-methylglyoxaline

3-Carbethoxythio-1-methyliminazole

Neomercazole

Ethyl 3-methyl-2-thioxo-Δ⁴-imidazoline-1-carboxylate

Basolest

Carbimazol

Neo-Thyreostat