[CAS NO. 152-62-5] Dydrogesterone

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PRODUCTS SPECIFICATIONS [152-62-5]

Catalog

SLK-S4097

Brand

Selleck

CAS

152-62-5

DESCRIPTION [152-62-5]

Overview

MDL	-
Molecular Weight	312.45
Molecular Formula	C21H28O2
SMILES	C[C@]12[C@]3([C@]([C@]4([C@](C)(CC3)[C@@H](C(C)=O)CC4)[H])(C=CC1=CC(=O)CC2)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.2005 mL	16.0026 mL	32.0051 mL
5 mM	0.6401 mL	3.2005 mL	6.4010 mL
10 mM	0.3201 mL	1.6003 mL	3.2005 mL
50 mM	0.0640 mL	0.3201 mL	0.6401 mL

Description

Dydrogesterone (NSC 92336) is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.

Targets

progestogen Receptor ^[1]

In vitro

Dydrogesterone alone or in combination with estrogen to endothelial cells results in neutral effects on NO synthesis and on the activity and expression of eNOS.

In vivo

Dydrogesterone abrogates stress-triggered increase of the abortion rate in mice. Dydrogesterone restores the percentage of CD8+ uterus cells back to levels seen in control mice. Dydrogesterone significantly lowers the relative number of TNF-α-producing uterine cells on days 7.5, 9.5, and even on 10.5 in mice. Dydrogesterone results in significantly higher percentages of pregnancy protective IL-4+ uterus cells beginning on gestation day 7.5 and, even more strikingly, maintained until day 10.5 in stressed mice. Dydrogesterone abrogates the highly elevated abortion rate of the abortion rate in mice exposured to sound stress. Dydrogesterone increases levels of plasma PIBF in stressed mice, but does not affect progesterone levels. Dydrogesterone dramatically increases the percentage of IL-4 positive decidual immune cells in stressed mice.

References

[1] Simoncini T, et al. Fertil Steril, 2006, 86, 1235-1242.
[2] Blois SM, et al. J Immunol, 2004, 172(10), 5893-5899.
[3] Joachim R, et al. Steroids, 2003, 68(10-13), 931-940.

Synonyms

Pregna-4,6-diene-3,20-dione, (9β,10α)-

9β,10α-Pregna-4,6-diene-3,20-dione

(9β,10α)-Pregna-4,6-diene-3,20-dione

6-Dehydro-9β,10α-progesterone

6α-Dehydro-retro-Δ⁴-pregnene-3,20-dione

6-Dehydroretroprogesterone

Diphaston

Dydrogesterone

Hydrogesterone

Retro-6-dehydroprogesterone

Retroprogesterone, 6-dehydro-

Terolut

Isopregnenone

Δ⁶-Retroprogesterone

Duphaston

Gestatron

Prodel

Retrone

Dufaston

Duvaron

Gynorest

NSC 92336