[CAS NO. 7177-48-2] Ampicillin Trihydrate

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PRODUCTS SPECIFICATIONS [7177-48-2]

Catalog

SLK-S4148

Brand

Selleck

CAS

7177-48-2

DESCRIPTION [7177-48-2]

Overview

MDL	MFCD00072036
Molecular Weight	403.45
Molecular Formula	C16H19N3O4S.3H2O
SMILES	C(O)(=O)[C@@H]1N2[C@@]([C@H](NC([C@H](N)C3=CC=CC=C3)=O)C2=O)(SC1(C)C)[H].O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4786 mL	12.3931 mL	24.7862 mL
5 mM	0.4957 mL	2.4786 mL	4.9572 mL
10 mM	0.2479 mL	1.2393 mL	2.4786 mL
50 mM	0.0496 mL	0.2479 mL	0.4957 mL

Description

Ampicillin Trihydrate (NCI-C56086,D-(-)-α-Aminobenzylpenicillin trihydrate) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Features

More effective than levofloxacin and ciprofloxacin against Streptococcus pneumoniae.

Targets

beta-lactamase ^[1]

In vitro

Ampicillin Trihydrate (500 mg) results in rapid bactericidal effect for SP34, the concentrations declines to the limit of detection (100 CFU/mL) during the initial 6 hours, and regrowth is not observed over the remaining 18 hours.

References

[1] Lacy MK, et al. Antimicrob Agents Chemother, 1999, 43(3), 672-677.
[2] Elsheikh HA, et al. J Vet Pharmacol Ther, 1997, 20(4), 262-266.
[3] Dunnick JK, et al. Toxicology, 1989, 56(2), 123-136.
[4] Membrez M, et al. FASEB J, 2008, 22(7), 2416-2426.
[5] Brown MP, et al. Equine Vet J, 1984, 16(4), 371-373.

Synonyms

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, hydrate (1:3), (2S,5R,6R)-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-, trihydrate, D-(-)-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, trihydrate, [2S-[2α,5α,6β(S*)]]-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, trihydrate, (2S,5R,6R)-

Ampicillin trihydrate

Polycillin

[D-(-)-α-Aminobenzyl]penicillin trihydrate

α-Aminobenzylpenicillin trihydrate

Aminobenzylpenicillin trihydrate

Principen