[CAS NO. 21256-18-8] Oxaprozin

Name: Oxaprozin
Brand: Arctom Scientific
SKU: SLK-S4230

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PRODUCTS SPECIFICATIONS [21256-18-8]

Fulfillment

Catalog

SLK-S4230

Brand

Selleck

CAS

21256-18-8

DESCRIPTION [21256-18-8]

Overview

MDL	MFCD00215977
Molecular Weight	293.32
Molecular Formula	C18H15NO3
SMILES	C(CC(O)=O)C1=NC(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.4092 mL	17.0462 mL	34.0925 mL
5 mM	0.6818 mL	3.4092 mL	6.8185 mL
10 mM	0.3409 mL	1.7046 mL	3.4092 mL
50 mM	0.0682 mL	0.3409 mL	0.6818 mL

Description

Oxaprozin (WY-21743,nsc 310839) is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

Targets

COX1 ^[1]

COX-2 ^[1]

In vitro

Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity.

References

[1] Kean WF, et al. Curr Med Res Opin, 2004, 20(8), 1275-1277.

Synonyms

2-Oxazolepropanoic acid, 4,5-diphenyl-

2-Oxazolepropionic acid, 4,5-diphenyl-

4,5-Diphenyl-2-oxazolepropanoic acid

β-(4,5-Diphenyloxazol-2-yl)propionic acid

Oxaprozin

4,5-Diphenyl-2-oxazolepropionic acid

Wy 21743

Daypro

Durapro

Alvo

Duraprost

Oxapro

NSC 310839

Actirin

3-(4,5-Diphenyloxazol-2-yl)propionic acid

Oxoprazine

3-(4,5-Diphenyloxazol-2-yl)propanoic acid