[CAS NO. 481-49-2] Cepharanthine

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Catalog:	SLK-S4238
Brand:	Selleck
CAS:	481-49-2

Overview

MDL	MFCD00210482
Molecular Weight	606.71
Molecular Formula	C37H38N2O6
SMILES	CN1[C@@]2(C=3C(=C4C(=CC3CC1)OCO4)OC=5C=C6[C@@](CC=7C=C(OC=8C=CC(C2)=CC8)C(OC)=CC7)(N(C)CCC6=CC5OC)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.6482 mL	8.2412 mL	16.4823 mL
5 mM	0.3296 mL	1.6482 mL	3.2965 mL
10 mM	0.1648 mL	0.8241 mL	1.6482 mL
50 mM	0.0330 mL	0.1648 mL	0.3296 mL

Description

Cepharanthine (NSC-623442) is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.

In vitro

Treatment of SaOS2 cells with Cepharanthine (CEP) (2.5-20 μmol/L) inhibits the cell growth in a concentration- and time-dependent manner. CEP (10 μmol/L) caused cell cycle arrest at G(1) phase and induced apoptosis of SaOS2 cells. CEP (10 and 15 μmol/L) significantly decreases the expression of STAT3 in SaOS2 cells. Furthermore, CEP (5 and 10 μmol/L) significantly inhibits the expression of target genes of STAT3, including the anti-apoptotic gene Bcl-xL and the cell cycle regulators c-Myc and cyclin D1.

In vivo

In nude mouse xenografts of SaOS2 cells, Cepharanthine (CEP) (20 mg•kg(-1)•d(-1), ip for 19 d) significantly reduces the volume and weight of the tumor.

References

[1] Chen Z, et al. Acta Pharmacol Sin, 2012, 33(1), 101-108.

Synonyms

1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2′,3′:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline, 2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-, (14aS,26aR)-

Cepharanthine

Oxyacanthan, 6′,12′-dimethoxy-2,2′-dimethyl-6,7-[methylenebis(oxy)]-

(14aS,26aR)-2,3,13,14,14a,15,26,26a-Octahydro-22,30-dimethoxy-1,14-dimethyl-1H-4,6:16,19-dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2′,3′:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline

O-Methylcepharanoline

Cepharanthin

Cepharantin

(+)-Cepharanthine

NSC 623442

SML 1269

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