[CAS NO. 747-36-4] Hydroxychloroquine Sulfate (NSC 4375)

Name: Hydroxychloroquine Sulfate (NSC 4375)
Brand: Arctom Scientific
SKU: SLK-S4430

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PRODUCTS SPECIFICATIONS [747-36-4]

Store

Catalog

SLK-S4430

Brand

Selleck

CAS

747-36-4

DESCRIPTION [747-36-4]

Overview

MDL	MFCD00078203
Molecular Weight	433.95
Molecular Formula	C18H28ClN3O5S
SMILES	N(C(CCCN(CCO)CC)C)C=1C2=C(N=CC1)C=C(Cl)C=C2.S(=O)(=O)(O)O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3044 mL	11.5221 mL	23.0441 mL
5 mM	0.4609 mL	2.3044 mL	4.6088 mL
10 mM	0.2304 mL	1.1522 mL	2.3044 mL
50 mM	0.0461 mL	0.2304 mL	0.4609 mL

Description

Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of and .

Targets

TLR9 ^[5]

Autophagy ^[1]

In vitro

Hydroxychloroquine Sulfate is a potent inhibitor of autophagy. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process.HCQ treatment inhibits RCC (renal cell cancer) cell growth, promotes apoptosis, inhibits mitochondrial oxygen consumption, and increases rates of glycolysis.

References

[1] Ramser B, et al.J Invest Dermatol, 2009,129(10):2419-26.
[2] Lee HO, et al. PLoS One. 2015, 10(7): e0131464.
[3] Bourke L, et al. PLoS One. 2015, 10(12):e0143771.
[4] Marta Mosca, et al. 2013 ACR/ARHP Annual Meeting.
[5] Lamphier M, et al. Mol Pharmacol. 2014, 85(3):429-440.

Synonyms

Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1)

Ethanol, 2-[[4-[(7-chloro-4-quinolyl)amino]pentyl]ethylamino]-, sulfate (1:1) (salt)

Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1) (salt)

7-Chloro-4-[4-N-ethyl-N-beta-hydroxyethylamino-1-methylbutylamino]quinoline sulfate

7-Chloro-4-[4-[ethyl(2-hydroxyethyl)amino]-1-methylbutylamino]-quinoline sulfate

Hydroxychloroquine sulfate

Plaquenil sulfate

Plaquenil

Quensyl

Ercoquin

NSC 4375

2-([4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino)ethan-1-ol; sulfuric acid

2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol sulfate

ZINC 01530654