[CAS NO. 5490-27-7] Dihydrostreptomycin sulfate

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PRODUCTS SPECIFICATIONS [5490-27-7]

Catalog

SLK-S4523

Brand

Selleck

CAS

5490-27-7

DESCRIPTION [5490-27-7]

Overview

MDL	-
Molecular Weight	1461.42
Molecular Formula	2C21H41N7O12.3H2SO4
SMILES	O([C@H]1[C@H](O[C@@H]2[C@@H](NC(=N)N)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]2O)O[C@@H](C)[C@@]1(CO)O)[C@H]3[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3.S(=O)(=O)(O)O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	0.6843 mL	3.4213 mL	6.8427 mL
5 mM	0.1369 mL	0.6843 mL	1.3685 mL
10 mM	0.0684 mL	0.3421 mL	0.6843 mL
50 mM	0.0137 mL	0.0684 mL	0.1369 mL

Description

Dihydrostreptomycin sulfate is an aminoglycoside , used to treat bacterial diseases in cattle, pigs and sheep. Dihydrostreptomycin is a derivative of streptomycin.

Targets

MET channel ^[1]

In vitro

The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins. It enters bacterial cells by binding to a specific site on MscL(mechanosensitive channel of large conductance) and modifying its conformation, thus allowing the passage of K+ and glutamate out of, and dihydrostreptomycin into, the cell.

In vivo

Dihydrostreptomycin sulfate would cause cochlea damage in mouse model and cell proliferation in the spiral ligament may occur after the dihydrostreptomycin sulfate -induced damage. This process is probably related to the recovery of cochlear function.

References

[1] Kimitsuki T, et al. Brain Res. 1993, 624(1-2):143-150.
[2] Yamashita H, et al. Acta Otolaryngol. 1999, 119(3):322-325.

Synonyms

D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N¹,N³-bis(aminoiminomethyl)-, sulfate (2:3)

Streptomycin, dihydro-, sulfate (2:3) (salt)

D-Streptamine, O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-(hydroxymethyl)-α-L-lyxofuranosyl-(1→4)-N,N′-bis(aminoiminomethyl)-, sulfate (2:3) (salt)

Dihydrostreptomycin 3/2 sulfate

Dihydrostreptomycin sulfate

Didromycine

Dihydrostreptomycin sesquisulfate

Panstreptin

Didromycin

Streptomagna

Double-mycin

Sol-Mycin