[CAS NO. 13171-25-0] Trimetazidine dihydrochloride

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PRODUCTS SPECIFICATIONS [13171-25-0]

Catalog

SLK-S4543

Brand

Selleck

CAS

13171-25-0

DESCRIPTION [13171-25-0]

Overview

MDL	-
Molecular Weight	339.26
Molecular Formula	C14H22N2O3.2HCl
SMILES	C(C1=C(OC)C(OC)=C(OC)C=C1)N2CCNCC2.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.9476 mL	14.7380 mL	29.4759 mL
5 mM	0.5895 mL	2.9476 mL	5.8952 mL
10 mM	0.2948 mL	1.4738 mL	2.9476 mL
50 mM	0.0590 mL	0.2948 mL	0.5895 mL

Description

Trimetazidine dihydrochloride (Yoshimilon, Kyurinett, Vastarel F) is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as inhibitor.

Targets

mitochondrial long-chain 3-ketoacyl thiolase ^[1]
(Cell-free assay)

75 nM

In vitro

Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion.

In vivo

The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia.

References

[1] Kantor PF, et al. Circ Res. 2000, 86(5):580-588.
[2] Liu Z, et al. Metabolism. 2016, 65(3):122-130.
[3] Yang Q, et al. Int J Clin Exp Pathol. 2015, 8(4):3735-3741.

Synonyms

Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)

Piperazine, 1-(2,3,4-trimethoxybenzyl)-, dihydrochloride

Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, dihydrochloride

Trimetazidine dihydrochloride

Vastarel

S 4004

1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride

Vastarel F

Yoshimilon

Kyurinett

Trivedon