[CAS NO. 96020-91-6] Eflornithine (MDL-71782) hydrochloride hydrate

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PRODUCTS SPECIFICATIONS [96020-91-6]

Catalog

SLK-S4582

Brand

Selleck

CAS

96020-91-6

DESCRIPTION [96020-91-6]

Overview

MDL	MFCD00242734
Molecular Weight	236.64
Molecular Formula	C6H12F2N2O2.HCl.H2O
SMILES	C(CCCN)(C(F)F)(C(O)=O)N.Cl.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.2258 mL	21.1291 mL	42.2583 mL
5 mM	0.8452 mL	4.2258 mL	8.4517 mL
10 mM	0.4226 mL	2.1129 mL	4.2258 mL
50 mM	0.0845 mL	0.4226 mL	0.8452 mL

Description

Eflornithine (Difluoromethylornithine, DFMO, MDL-71782, RMI-71782, α-difluoromethylornithine) hydrochloride hydrate inhibits by the selective, irreversible inhibition of . A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.

Targets

Orn decarboxylase ^[2]

In vitro

When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur.

References

[1] Yoda H, et al. Plant Physiol. 2006, 142(1):193-206.
[2] Yoda H, et al. Plant Physiol. 2003, 132(4):1973-81.
[3] Lipke DW, et al. Clin Exp Hypertens. 1997 Apr;19(3):297-312.

Synonyms

Ornithine, 2-(difluoromethyl)-, hydrochloride, hydrate (1:1:1)

DL-Ornithine, 2-(difluoromethyl)-, monohydrochloride, monohydrate

Ornithine, 2-(difluoromethyl)-, monohydrochloride, monohydrate

2,5-Diamino-2-(difluoromethyl)pentanoic acid hydrate hydrochloride