[CAS NO. 31431-39-7] Mebendazole

Name: Mebendazole
Brand: Arctom Scientific
SKU: SLK-S4610

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PRODUCTS SPECIFICATIONS [31431-39-7]

Distributor

Catalog

SLK-S4610

Brand

Selleck

CAS

31431-39-7

DESCRIPTION [31431-39-7]

Overview

MDL	MFCD00057872
Molecular Weight	295.29
Molecular Formula	C16H13N3O3
SMILES	C(=O)(C=1C=C2C(N=C(NC(OC)=O)N2)=CC1)C3=CC=CC=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.3865 mL	16.9325 mL	33.8650 mL
5 mM	0.6773 mL	3.3865 mL	6.7730 mL
10 mM	0.3387 mL	1.6933 mL	3.3865 mL
50 mM	-	-	-

Description

Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.

In vitro

mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells.

In vivo

When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice.

References

[1] Liu C, et al. Parasitol Res. 2015, 114(6):2213-22.
[2] Mukhopadhyay T, et al. Clin Cancer Res. 2002, 8(9):2963-2969.

Synonyms

Carbamic acid, N-(6-benzoyl-1H-benzimidazol-2-yl)-, methyl ester

2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester

Carbamic acid, (5-benzoyl-1H-benzimidazol-2-yl)-, methyl ester

Mebendazole

Methyl 5-benzoyl-2-benzimidazolecarbamate

R 17635

Methyl 5-benzoyl-2-benzimidazolylcarbamate

(5-Benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl ester

5-Benzoyl-2-benzimidazolecarbamic acid methyl ester

Pantelmin

Telmin

Vermox

Mebenvet

Ovitelmin

Besantin

NSC 184849

Verpanyl

Mebex

Equivurm Plus

Vermirax

Bantenol

Noverme

Lomper

Vermicidin

Zhihuanqing

Vermoxine