[CAS NO. 57-96-5] (+/-)-Sulfinpyrazone

Name: (+/-)-Sulfinpyrazone
Brand: Arctom Scientific
SKU: SLK-S4628

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PRODUCTS SPECIFICATIONS [57-96-5]

Distributor

Catalog

SLK-S4628

Brand

Selleck

CAS

57-96-5

DESCRIPTION [57-96-5]

Overview

MDL	MFCD00057279
Molecular Weight	404.48
Molecular Formula	C23H20N2O3S
SMILES	O=C1N(N(C(=O)C1CCS(=O)C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4723 mL	12.3616 mL	24.7231 mL
5 mM	0.4945 mL	2.4723 mL	4.9446 mL
10 mM	0.2472 mL	1.2362 mL	2.4723 mL
50 mM	0.0494 mL	0.2472 mL	0.4945 mL

Description

Sulfinpyrazone (G-28315, NSC 75925) is one of the most studied , also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.

Targets

platelet-release reaction ^[2]

In vivo

Sulfinpyrazone exerts significant electrophysiologic actions under various experimental conditions. It raises the ventricular fibrillation threshold as well as the mid diastolic threshold and prolongs the effective refractory period. In the acutely ischemic heart, it attenuates the effect of coronary occlusion on the ventricular fibrillation threshold but has no effect after reperfusion. A protective influence of the drug is also evident during sympathetic humoral stimulation with norepinephrine. The antifibrillatory effect of sulfinpyrazone is additive to the changes elicited by beta adrenergic blockade with practolol or cardiac membrane stabilization with lidocaine.

References

[1] Raeder EA, et al. Am J Cardiol. 1982, 50(2):271-275.
[2] Rosenberg JC, et al. Arch Surg. 1975, 110(8):980-983.

Synonyms

3,5-Pyrazolidinedione, 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-

1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione

G 28315

Anturan

Anturane

1,2-Diphenyl-4-(2′-phenylsulfinethyl)-3,5-pyrazolidinedione

Diphenylpyrazone

4-(Phenylsulfoxyethyl)-1,2-diphenyl-3,5-pyrazolidinedione

Sulfinpyrazone

Sulfoxyphenylpyrazolidine

Sulphinpyrazone

Sulfinpyrazon

Anturanil

Anturen

Anturidin

Enturan

Enturen

NSC 75925