[CAS NO. 126544-47-6] Ciclesonide

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Catalog:	SLK-S4646
Brand:	Selleck
CAS:	126544-47-6

Overview

MDL	-
Molecular Weight	540.69
Molecular Formula	C32H44O7
SMILES	C(COC(C(C)C)=O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@](O2)([C@@H]4CCCCC4)[H])[H])([C@]5([C@]([C@@H](O)C3)([C@]6(C)C(CC5)=CC(=O)C=C6)[H])[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8495 mL	9.2474 mL	18.4949 mL
5 mM	0.3699 mL	1.8495 mL	3.6990 mL
10 mM	0.1849 mL	0.9247 mL	1.8495 mL
50 mM	0.0370 mL	0.1849 mL	0.3699 mL

Description

Ciclesonide (Alvesco, Omnaris, RPR251526, Zetonna) is a glucocorticoid used to treat obstructive airway diseases.

In vitro

Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC.

References

[1] Guo Z, et al. Am J Ther. 2006, 13(6):490-501.
[2] Nonaka T, et al. BMC Pharmacol. 2007, 7:12.

Synonyms

Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11β,16α)-

Pregna-1,4-diene-3,20-dione, 16,17-[(cyclohexylmethylene)bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, [11β,16α(R)]-

2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregna-1,4-diene-3,20-dione deriv.

(11β,16α)-16,17-[[(R)-Cyclohexylmethylene]bis(oxy)]-11-hydroxy-21-(2-methyl-1-oxopropoxy)pregna-1,4-diene-3,20-dione

Ciclesonide

(R)-11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate

RPR 251526

Alvesco

Omnaris

Cinase

BI 54903

Aservo EquiHaler

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