[CAS NO. 24868-20-0] Dantrolene sodium hemiheptahydrate

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PRODUCTS SPECIFICATIONS [24868-20-0]

Catalog

SLK-S4648

Brand

Selleck

CAS

24868-20-0

DESCRIPTION [24868-20-0]

Overview

MDL	MFCD07357270
Molecular Weight	399.29
Molecular Formula	C14H9N4O5.7/2H2O.Na
SMILES	C(=NN1CC(=O)NC1=O)C=2OC(=CC2)C3=CC=C(N(=O)=O)C=C3.[Na].O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Dantrolene sodium hemiheptahydrate (Dantrium) ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.

In vitro

Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. Dantrolene sodium shows strong antioxidant activity in the linoleic acid emulsion system.

In vivo

Dantrolene sodium (5 mg/kg) has a greater depressant action on the twitch contraction of the fast extensor digitorum longus (EDL) muscle than on the slow soleus (SOL) muscle.

References

[1] Leslie GC, et al. Br J Pharmacol. 1981, 72(4):665-72.
[2] Büyükokuroğlu ME, et al. Pharmacol Res. 2001, 44(6):491-4.

Synonyms

2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt, hydrate (2:2:7)

Hydantoin, 1-[[5-(p-nitrophenyl)furfurylidene]amino]-, sodium salt, hydrate (2:7)

2,4-Imidazolidinedione, 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-, sodium salt, hydrate (2:7)

1-[[5-(p-Nitrophenyl)furfurylidene]amino]hydantoin sodium salt hydrate