[CAS NO. 198470-84-7] Parecoxib

Name: Parecoxib
Brand: Arctom Scientific
SKU: SLK-S4656

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PRODUCTS SPECIFICATIONS [198470-84-7]

Distributor

Catalog

SLK-S4656

Brand

Selleck

CAS

198470-84-7

DESCRIPTION [198470-84-7]

Overview

MDL	MFCD25976408
Molecular Weight	370.42
Molecular Formula	C19H18N2O4S
SMILES	CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(NC(CC)=O)(=O)=O)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.6996 mL	13.4982 mL	26.9964 mL
5 mM	0.5399 mL	2.6996 mL	5.3993 mL
10 mM	0.2700 mL	1.3498 mL	2.6996 mL
50 mM	0.0540 mL	0.2700 mL	0.5399 mL

Description

Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective inhibitor.

Targets

COX2 ^[1]

In vivo

Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH.

References

[1] Meunier A, et al. Arch Orthop Trauma Surg. 2006, 126(7):433-6.
[2] Chih-Zen Chang, et al. Journal of Neurology & Neurophysiology. 2015.

Synonyms

Propanamide, N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]-

N-[[4-(5-Methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propanamide

Parecoxib

SC 69124

Vorth-P

Valus-P

Xapit