[CAS NO. 117976-90-6] Rabeprazole sodium

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PRODUCTS SPECIFICATIONS [117976-90-6]

Catalog

SLK-S4665

Brand

Selleck

CAS

117976-90-6

DESCRIPTION [117976-90-6]

Overview

MDL	MFCD02092688
Molecular Weight	381.42
Molecular Formula	C18H20N3O3S.Na
SMILES	S(CC1=C(C)C(OCCCOC)=CC=N1)(=O)C=2NC=3C(N2)=CC=CC3.[Na]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.6218 mL	13.1089 mL	26.2178 mL
5 mM	0.5244 mL	2.6218 mL	5.2436 mL
10 mM	0.2622 mL	1.3109 mL	2.6218 mL
50 mM	0.0524 mL	0.2622 mL	0.5244 mL

Description

Rabeprazole (Aciphex, Dexrabeprazole, Habeprazole) is an drug in the class of inhibitors.

Targets

proton pump ^[1]

In vitro

Administration of rabeprazole leads to a marked decrease in the viability of MKN-28 cells. Exposure to rabeprazole induces significant apoptosis in AGS cells. Rabeprazole completely inhibits the phosphorylation of ERK 1/2 in the MKN-28 cells, whereas the same effect is not observed in either the KATO III or MKN-45 cells. Rabeprazole is able to efficaciously inhibit the phosphorylation of ERK 1/2 in the gastric cancer cells.Thus, rabeprazole can attenuate the cell viability of human gastric cancer cells through inactivation of the ERK1/2 signaling pathway.

In vivo

Rabeprazole does not appear to exacerbate bone metabolic disorders in gastrectomized rats, but rather ameliorates the TG-induced BMD decrease.

References

[1] Yamasaki Y, et al. Biomed Rep. 2016, 5(1):118-124.
[2] Gu M, et al. Oncol Lett. 2014, 8(4):1739-1744.

Synonyms

1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-, sodium salt (1:1)

1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-, sodium salt

E 3810

LY 307640 sodium

Rabeprazole sodium

Pariprazole

Pariet

Aciphex

2-[[[4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methyl]sulfinyl]-1H-benzimidazole sodium salt

Rabicip

Pepcia

Razo