[CAS NO. 107-97-1] Sarcosine

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PRODUCTS SPECIFICATIONS [107-97-1]

Catalog

SLK-S4702

Brand

Selleck

CAS

107-97-1

DESCRIPTION [107-97-1]

Overview

MDL	MFCD00004279
Molecular Weight	89.09
Molecular Formula	C3H7NO2
SMILES	C(C(O)=O)NC

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	11.2246 mL	56.1230 mL	112.2460 mL
5 mM	2.2449 mL	11.2246 mL	22.4492 mL
10 mM	1.1225 mL	5.6123 mL	11.2246 mL
50 mM	0.2245 mL	1.1225 mL	2.2449 mL

Description

Sarcosine (N-methylglycine, Sarcosinic acid, Methylaminoacetic acid, Methylglycine) is a competitive inhibitor of the and an co-agonist.

Targets

GlyT1 ^[1]

N-methyl-D-aspartate receptor ^[1]

GlyR ^[1]

In vitro

Sarcosine is a GlyR agonist in addition to being a GlyT1 inhibitor and NMDAR co-agonist, but it is less potent than glycine as a GlyR agonist and is not a full agonist. The viability of the sarcosine-treated cells is significantly reduced.

In vivo

Sarcosine has weak anticonvulsant properties. It ameliorates (prepulse inhibition)PPI deficits in mGluR5 knockout mice.

References

[1] Zhang HX, et al. Neuropharmacology. 57(5-6):551-5.
[2] Socała K, et al. Pharmacol Rep. 2010, 62(2):392-7.
[3] Chen HH, et al. Psychopharmacology (Berl). 2010, 209(4):343-50.

Synonyms

Glycine, N-methyl-

Sarcosine

N-Methylglycine

Acetic acid, (methylamino)-

(Methylamino)acetic acid

N-Methylaminoacetic acid

(Methylamino)ethanoic acid

Sarcosinic acid

Sarcosin

Methylglycine

2-(Methylamino)acetic acid

2-(Methylazaniumyl)acetate