[CAS NO. 298-57-7] Cinnarizine

Name: Cinnarizine
Brand: Arctom Scientific
SKU: SLK-S4727

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PRODUCTS SPECIFICATIONS [298-57-7]

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Catalog

SLK-S4727

Brand

Selleck

CAS

298-57-7

DESCRIPTION [298-57-7]

Overview

MDL	MFCD00056037
Molecular Weight	368.51
Molecular Formula	C26H28N2
SMILES	C(N1CCN(CC=CC2=CC=CC=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7136 mL	13.5682 mL	27.1363 mL
5 mM	0.5427 mL	2.7136 mL	5.4273 mL
10 mM	0.2714 mL	1.3568 mL	2.7136 mL
50 mM	-	-	-

Description

Cinnarizine (Stugeron, Dimitronal, Stutgin, Cinarizine) is a medication derivative of piperazine, and characterized as an and a blocker.

Targets

Calcium channel ^[1]

Histamine receptor ^[3]

In vitro

Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists.

In vivo

Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism. Its half-life is 4 hours.

References

[1] Krzysztof Sendrowski, et al. Pharmacological Reports. 2013, 65(3):730-736.
[2] Brahmane RI, et al. J Pharmacol Pharmacother. 2010, 1(2):78-81.
[3] Serrano A, et al. Neuropharmacology. 2005, 49(2):208-19.

Synonyms

Piperazine, 1-(diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)-

Piperazine, 1-cinnamyl-4-(diphenylmethyl)-

Piperazine, 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-

1-(Diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)piperazine

R 516

R 1575

N-Benzhydryl-N′-cinnamylpiperazine

1-Cinnamyl-4-(diphenylmethyl)piperazine

Cinnarizine

Dimitronal

1-Diphenylmethyl-4-cinnamoylpiperazine

Marisan

Midronal

Mitronal

Stugeron

Glanil

Labyrin

Dimitron

Stutgeron

Stutgin

Toliman

Folcodal

Sepan

1-Benzhydryl-4-cinnamylpiperazine

Lazeta

1-Cinnamyl-4-benzhydrylpiperazine

1-(3-Phenylallyl)-4-(diphenylmethyl)piperazine

Artate

Cinazyn

Apotomin

Corathiem

Cinaperazine

Katoseran

Giganten

Cerepar

Spaderizine

Cinnageron

Cerebolan

Hilactan

Cinnipirine

Denapol

Eglen

Carecin

Cinnacet

Sedatromin

Ixterol

Siptazin

Aplactan

Olamin

516MD

Processine

Aplexal

Cinarizine

Vergo

Stunarone