[CAS NO. 59729-32-7] Citalopram HBr

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PRODUCTS SPECIFICATIONS [59729-32-7]

Catalog

SLK-S4749

Brand

Selleck

CAS

59729-32-7

DESCRIPTION [59729-32-7]

Overview

MDL	MFCD02101306
Molecular Weight	405.3
Molecular Formula	C20H21FN2O.HBr
SMILES	C(CCN(C)C)C1(C=2C(CO1)=CC(C#N)=CC2)C3=CC=C(F)C=C3.Br

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.4673 mL	12.3365 mL	24.6731 mL
5 mM	0.4935 mL	2.4673 mL	4.9346 mL
10 mM	0.2467 mL	1.2337 mL	2.4673 mL
50 mM	0.0493 mL	0.2467 mL	0.4935 mL

Description

Citalopram HBr (Nitalapram HBr, Prepram HBr, Bonitrile HBr, Lu 10-171 HBr), an antidepressant, is an orally administered selective inhibitor (SSRI) with of 1.8 nM.

Targets

serotonin reuptake ^[1]
(In rat brain synaptosomal preparations)

1.8 nM

In vitro

Citalopram (Lu 10-171), a new bicyclic phthalane derivative, is an extremely potent inhibitor of neuronal serotonin (5-HT) uptake but has no effect on the uptake of noradrenaline(NA) and dopamine (DA) and no antagonistic activity towards 5-HT, histamine, gamma aminobutyric acid (GABA), acetylcholine, and morphine receptors. It is an extremely specific and potent inhibitor of neuronal 5-HT uptake. Uptake mechanisms for other transmitter amines are not influenced by the drug. The SSRI citalopram has a greater effect on proliferation and a lesser effect on apoptotic activity. It affects cell cycle regulation by increasing proliferative potential and decreasing apoptotic activity in a site specific manner that may be indicative of hyperplasia. Citalopram alters FGF, MSX and TGFB expression in osteoblast cell culture.

In vivo

Citalopram is devoid of cardiotoxic effects even when animals are exposed to concentrations far above the therapeutic level. In man citalopram is metabolized to compounds which are also potent 5-HT-uptake inhibitors without effect on noradrenaline(NA) uptake and which are found in lower concentrations than citalopram itself. Citalopram (1-16 mg/kg) stimulates the hind limb flexor reflex in the spinal rat. Citalopram potentiates 5-HT transmission~ possibly by producing very strong uptake inhibition without simultaneously blocking the post-synaptic 5-HT receptors.

References

[1] Hyttel J. Prog Neuropsychopharmacol Biol Psychiatry. 1982, 6(3):277-95.
[2] Pollier F, et al. Neuropsychopharmacology. 2000, 22(1):64-76.
[3] Durham E, et al. PLoS One. 2015, 10(10):e0139719.

Synonyms

5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, hydrobromide (1:1)

5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, monohydrobromide

Citalopram hydrobromide

Seropram

Cipramil

Celexa

Cipram

Lupram

Apertia

Sepram

Lu 10-171B

Elopram

Prisdal

(±)-Citalopram hydrobromide

Lecital

S-Pram

Pramcit

Cheer

Citopram

[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-isobenzofuran-5-carbonitrile hydrobromide

1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile hydrobromide