[CAS NO. 21593-77-1] S-allyl-L-cysteine

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PRODUCTS SPECIFICATIONS [21593-77-1]

Catalog

SLK-S4791

Brand

Selleck

CAS

21593-77-1

DESCRIPTION [21593-77-1]

Overview

MDL	MFCD00151975
Molecular Weight	161.22
Molecular Formula	C6H11NO2S
SMILES	[C@H](CSCC=C)(C(O)=O)N

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	6.2027 mL	31.0135 mL	62.0270 mL
5 mM	1.2405 mL	6.2027 mL	12.4054 mL
10 mM	0.6203 mL	3.1014 mL	6.2027 mL
50 mM	0.1241 mL	0.6203 mL	1.2405 mL

Description

S-Allyl cysteine (SAC, S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals. S-Allyl cysteine has an anticancer effect through the induction of and a cell cycle arrest.

In vitro

S-Allyl cysteine (SAC) could suppress NF-κB activation and lower nitric oxide (NO) production in interferon-γ-stimulated RAW264.7 cells. SAC is known for its anti-apoptotic and antioxidant effects in a range of types of somatic cells. SAC manifests antioxidant properties for example in the nervous and cardiovascular systems.

In vivo

SAC significantly prevents NSAID-induced gastric ulceration by blocking inflammation. The dietary intake of SAC suppresses protein expression of NF-κB, MAPK, and PKC in kidney of diabetic mice, which in turn declines renal activity and mRNA expression of NOS and COX-2, finally lowers the formation of ROS, nitric oxide, IL-6, TNF-α, and PGE2, as well as improves renal functions. Therefore, SAC is potent anti-inflammatory agents against diabetic nephropathy.

References

[1] Park JM, et al. J Gastroenterol Hepatol. 2014, 29 Suppl 4:80-92.
[2] Mong MC, et al. J Agric Food Chem. 2012 Mar 28;60(12):3158-65.
[3] Dvořáková M, et al. PeerJ. 2016, 4:e2280.

Synonyms

L-Cysteine, S-2-propen-1-yl-

Alanine, 3-(allylthio)-, L-

L-Cysteine, S-2-propenyl-

Alanine, 3-(allylthio)-

S-2-Propen-1-yl-L-cysteine

S-Allyl-L-cysteine

3-(Allylthio)-L-alanine

S-Allylcysteine

S-2-Propenylcysteine

S-(2-Propenyl)-L-cysteine

Deoxyalliin

(+)-S-Allylcysteine

NSC 96449

PMK-S 005

(2R)-2-Amino-3-(prop-2-en-1-ylsulfanyl)propanoic acid

(2R)-2-Azaniumyl-3-prop-2-enylsulfanylpropanoate

S-1-Propenylmercaptocysteine