[CAS NO. 50847-11-5] Ibudilast

Name: Ibudilast
Brand: Arctom Scientific
SKU: SLK-S4837

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PRODUCTS SPECIFICATIONS [50847-11-5]

Distributor

Catalog

SLK-S4837

Brand

Selleck

CAS

50847-11-5

DESCRIPTION [50847-11-5]

Overview

MDL	MFCD00864808
Molecular Weight	230.31
Molecular Formula	C14H18N2O
SMILES	C(C(C)C)(=O)C1=C2N(N=C1C(C)C)C=CC=C2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Ibudilast (KC-404, AV411, MN166) is a relatively non-selective inhibitor with anti-inflammatory and neuroprotective activities.

Targets

PDE4 ^[1] (Bovine aortic EC)	PDE2 ^[1] (Bovine aortic EC)	PDE5 ^[1] (Human platelets)
0.08 μM	0.11 μM	2.2 μM

In vitro

Ibudilast suppressses pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), toll-like receptor 4 blockade (TLR-4); inhibits a macrophage migration inhibitory factor (MIF), upregulates the anti‑inflammatory cytokine (IL-10) and promotes neurotrophic factors (GDNF, NGF, NT‑4).

In vivo

Ibudilast crosses the blood-brain barrier and has a good tolerance in vivo. It inhibits platelet aggregation, improves cerebral blood flow and attenuates allergic reactions in clinical applications. In an animal model of encephalomyelitis, Ibudilast significantly attenuates inflammatory cell infiltration in the lumbar spinal cord. After oral administration, it is well absorbed and metabolized in the liver mainly to diOH-ibudilast, which has similar or even stronger pharmacological effects.

References

[1] Kishi Y, et al. Cardiovasc Drug Rev. 2001, 19(3):215-25.
[2] Nishimura H, et al. Stroke. 1996, 27(6):1099-103;

Synonyms

1-Propanone, 2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-

Pyrazolo[1,5-a]pyridine, 1-propanone deriv.

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone

2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine

KC 404

Ibudilast

Ketas

3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine

1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one

AV 411

Pinatos

2-Methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one