[CAS NO. 1134-47-0] Baclofen

Name: Baclofen
Brand: Arctom Scientific
SKU: SLK-S4840

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PRODUCTS SPECIFICATIONS [1134-47-0]

Distributor

Catalog

SLK-S4840

Brand

Selleck

CAS

1134-47-0

DESCRIPTION [1134-47-0]

Overview

MDL	MFCD00055143
Molecular Weight	213.66
Molecular Formula	C10H12ClNO2
SMILES	C(CC(O)=O)(CN)C1=CC=C(Cl)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.6803 mL	23.4017 mL	46.8033 mL
5 mM	0.9361 mL	4.6803 mL	9.3607 mL
10 mM	0.4680 mL	2.3402 mL	4.6803 mL
50 mM	-	-	-

Description

Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant and central nervous system depressant. It activates , specifically the GABAB receptors.

Targets

GABAB receptor ^[2]

In vitro

Baclofen induces G0/G1 phase arrest which is connected with down-regulation of intracellular cAMP level, and up-regulation of p21 protein expression as well as its phosphorylation level in human hepatocellular carcinoma cell.

In vivo

Chronic treatment with baclofen markedly diminishes hippocampal atrophy and neuronal apoptosis in hippocampal CA1 area via the regulation of autophagy in chronic cerebral hypoperfusion in rats. Baclofen might suppress cytodestructive autophagic activity through Akt-GSK-3β-p-mTOR-Beclin 1 signaling pathway under chronic cerebral hypoperfusion. During brain ischemia, baclofen could reduce CX43 and CX36 surface expression. Baclofen-induced suppression of increased CX43 and CX36 surface expressions helps neurons survive. Baclofen reduces reinstatement to cocaine self-administration in an animal model of relapse. Baclofen suppresses Bel-7402 xenograft tumor growth in vivo.

References

[1] Li Liu, et al. Scientific Reports. 2015, 5: 14474.
[2] Di Ciano P, et al. Neuropsychopharmacology. 2003, 28(3):510-8.
[3] Wang T, et al. Life Sci. 2008, 82(9-10):536-41.

Synonyms

Benzenepropanoic acid, β-(aminomethyl)-4-chloro-

Hydrocinnamic acid, β-(aminomethyl)-p-chloro-

β-(Aminomethyl)-4-chlorobenzenepropanoic acid

β-(Aminomethyl)-p-chlorohydrocinnamic acid

β-(4-Chlorophenyl)-γ-aminobutyric acid

Baclofen

Lioresal

Ba 34647

β-(p-Chlorophenyl)-γ-aminobutyric acid

β-p-Chlorophenyl-GABA

CIBA Ba 34647

4-Amino-3-(4-chlorophenyl)butyric acid

C 34647Ba

4-Amino-3-(p-chlorophenyl)butyric acid

DL-4-Amino-3-p-chlorophenylbutanoic acid

dl-Baclofen

(±)-Baclofen

DL-Baclofen

Baclon

4-Amino-3-(4-chlorophenyl)butanoic acid

(±)-4-Amino-3-(4-chlorophenyl)butanoic acid