[CAS NO. 206184-49-8] Tenofovir hydrate

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Catalog:	SLK-S4879
Brand:	Selleck
CAS:	206184-49-8

Overview

MDL	MFCD11519982
Molecular Weight	305.23
Molecular Formula	C9H16N5O5P
SMILES	C([C@H](OCP(=O)(O)O)C)N1C=2C(N=C1)=C(N)N=CN2.O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.2762 mL	16.3811 mL	32.7622 mL
5 mM	0.6552 mL	3.2762 mL	6.5524 mL
10 mM	0.3276 mL	1.6381 mL	3.2762 mL
50 mM	-	-	-

Description

Tenofovir (GS-1278) hydrate blocks and infections.

In vitro

Tenofovir reduces the viral cytopathic effect of HIV-1(IIIB), HIV-2(ROD) and HIV(EHO) with EC50 of 1.15 μg/mL, 1.12 μg/mL and 1.05 μg/mL in MT-4 cells. Tenofovir also reduces the viral cytopathic effect of SIV(mac251) , SIV(B670) ,SHIV(89.6) and SHIV(RTSHIV). Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. Tenofovir inhibits hepatitis B virus (HBV) activity in HepG2 2.2.15, HepAD38 and HepAD79 cells. Tenofovir (4 μM) completely inhibits the growth of HIVIIIB in MT-2 cells. Tenofovir inhibits synthesis of negative strand strong-stop DNA with IC50 of 9 µM for wild-type RT, 6 µM for M184V RT and 50 µM for K65R RT.

References

[6] Myriam Witvrouw, et al. Antivir Ther. 2004 Feb;9(1):57-65.
[1] Witvrouw M, et al. Antivir Ther. 2004 Feb;9(1):57-65.
[2] Miller MD, et al. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1025-8.
[3] Ying C, et al. J Viral Hepat. 2000 Mar;7(2):161-5.
[4] Wainberg MA, et al. Antivir Ther. 1999;4(2):87-94.
[5] De Clercq E. Clin Microbiol Rev. 2003 Oct;16(4):569-96.

Synonyms

Phosphonic acid, P-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, hydrate (1:1)

Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monohydrate, (R)-

Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, monohydrate

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