[CAS NO. 2921-14-4] AOA hemihydrochloride

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PRODUCTS SPECIFICATIONS [2921-14-4]

Catalog

SLK-S4989

Brand

Selleck

CAS

2921-14-4

DESCRIPTION [2921-14-4]

Overview

MDL	MFCD00012955
Molecular Weight	109.3
Molecular Formula	C2H5NO3.1/2HCl
SMILES	C(C(O)=O)ON.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	9.1491 mL	45.7457 mL	91.4913 mL
5 mM	1.8298 mL	9.1491 mL	18.2983 mL
10 mM	0.9149 mL	4.5746 mL	9.1491 mL
50 mM	0.1830 mL	0.9149 mL	1.8298 mL

Description

AOA hemihydrochloride (Aminooxyacetic acid, Carboxymethoxylamine, AOAA, Aminooxyacetate hemihydrochloride) is an inhibitor of involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a inhibitor.

Targets

GABA-T ^[1]

Malate-aspartate shuttle ^[1]

In vitro

Aminooxyacetic acid (AOAA) is a malate-aspartate shuttle inhibitor, leading to decreased intracellular ATP levels and altering cell cycle and increasing apoptosis and necrosis of C6 glioma cells, without affecting the survival of primary astrocyte cultures. AOAA also decreases the glycolytic rate and the levels of extracellular lactate and pyruvate, without affecting the mitochondrial membrane potential of C6 cells. Aminooxyacetic acid can selectively inhibit the proliferation of breast cancer cells.

In vivo

Aminooxyacetic acid suppresses the growth of breast adenocarcinoma in athymic mice. AOAA is much less toxic in rats than in mice.

References

[1] Wang C, et al. Cancer Lett. 2016, 378(1):1-7.
[2] Löscher W, et al. J Neurochem. 1989, 53(6):1737-50.

Synonyms

Acetic acid, 2-(aminooxy)-, hydrochloride (2:1)

Acetic acid, (aminooxy)-, hydrochloride (2:1)

Acetic acid, (aminooxy)-, hemihydrochloride

Aminooxyacetic acid hemihydrochloride

Carboxymethoxyamine hemihydrochloride

O-Carboxymethylhydroxylamine hemihydrochloride

Carboxymethoxylamine hemihydrochloride

Aminooxyacetic acid hemichloride