[CAS NO. 1063-77-0] Nomilin

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PRODUCTS SPECIFICATIONS [1063-77-0]

Catalog

SLK-S5045

Brand

Selleck

CAS

1063-77-0

DESCRIPTION [1063-77-0]

Overview

MDL	MFCD00075979
Molecular Weight	514.56
Molecular Formula	C28H34O9
SMILES	C[C@]12[C@]34[C@](C)([C@@](OC(=O)[C@]3(O4)[H])(C=5C=COC5)[H])CC[C@@]1([C@]6(C)[C@@](CC2=O)(C(C)(C)OC(=O)C[C@@H]6OC(C)=O)[H])[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9434 mL	9.7170 mL	19.4341 mL
5 mM	0.3887 mL	1.9434 mL	3.8868 mL
10 mM	0.1943 mL	0.9717 mL	1.9434 mL
50 mM	0.0389 mL	0.1943 mL	0.3887 mL

Description

Nomilin is a triterpenoid present in common edible citrus fruits with putative anticancer properties.

In vitro

Administration of nomilin significantly retarded endothelial cell proliferation, migration, invasion and tube formation. It also possesses anti-proliferative activity against number of human cancer cell lines including leukemia (HL-60), ovary (SKOV-3), cervix (HeLa), stomach (NCI-SNU-1), liver (Hep G2), and breast (MCF-7). Nomilin significantly decreased TRAP-positive multinucleated cell numbers compared with the control, and exhibited no cytotoxicity. It decreases bone resorption activity and downregulates osteoclast-specific genes, NFATc1 and TRAP mRNA levels. Furthermore, nomilin suppressed MAPK signaling pathways. Thus, nomilin has inhibitory effects on osteoclastic differentiation in vitro.

In vivo

Apart from antifeedant activity, Nomilin is a potent inducers of gluthathione S-transferase activity in mice and to inhibit carcinogenesis in the hamster buccal pouch assay. Nomilin can shorten anaesthetic-induced sleeping time in mice, probably through a stimulant activity on the central nervous system. Nomilin significantly inhibited tumor directed capillary formation. Serum proinflammatory cytokines such as IL-1β, IL-6, TNF-α and GM-CSF and also serum NO levels were significantly reduced by the treatment of nomilin. Administration of nomilin significantly reduced the serum level of VEGF, a proangiogenic factor and increased the antiangiogenic factors IL-2 and TIMP-1.

References

[1] Battinelli L, et al. Planta Med. 2003, 69(10):910-3.
[2] Pratheeshkumar P, et al. Eur J Pharmacol. 2011, 668(3):450-8.
[3] Kimira Y, et al. Phytomedicine. 2015, 22(12):1120-4.

Synonyms

Oxireno[4,4a]-2-benzopyrano[6,5-g][2]benzoxepin-3,5,9(3aH,4bH,6H)-trione, 11-(acetyloxy)-1-(3-furanyl)decahydro-4b,7,7,11a,13a-pentamethyl-, (1S,3aS,4aR,4bR,6aR,11S,11aR,11bR,13aS)-

Oxireno[4,4a]-2-benzopyrano[6,5-g][2]benzoxepin-3,5,9(3aH,4bH,6H)-trione, 1-(3-furyl)decahydro-11-hydroxy-4b,7,7,11a,13a-pentamethyl-, acetate

Nomilin

Obacunoic acid, 1-(acetyloxy)-1,2-dihydro-, ε-lactone

(1S,3aS,4aR,4bR,6aR,11S,11aR,11bR,13aS)-11-(Acetyloxy)-1-(3-furanyl)decahydro-4b,7,7,11a,13a-pentamethyloxireno[4,4a]-2-benzopyrano[6,5-g][2]benzoxepin-3,5,9(3aH,4bH,6H)-trione

Oxireno[4,4a]-2-benzopyrano[6,5-g][2]benzoxepin-3,5,9(3aH,4bH,6H)-trione, 11-(acetyloxy)-1-(3-furanyl)decahydro-4b,7,7,11a,13a-pentamethyl-, [1S-(1α,3aα,4aS*,4bβ,6aα,11α,11aβ,11bα,13aα)]-

NSC 297134