[CAS NO. 106941-25-7] Adefovir

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Catalog:	SLK-S5068
Brand:	Selleck
CAS:	106941-25-7

Overview

MDL	MFCD00866943
Molecular Weight	273.19
Molecular Formula	C8H12N5O4P
SMILES	C(COCP(=O)(O)O)N1C=2C(N=C1)=C(N)N=CN2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.6605 mL	18.3023 mL	36.6046 mL
5 mM	0.7321 mL	3.6605 mL	7.3209 mL
10 mM	0.3660 mL	1.8302 mL	3.6605 mL
50 mM	-	-	-

Description

Adefovir is an orally administered nucleotide analog inhibitor used for treatment of hepatitis B and herpes simplex virus infection.

Targets

Reverse transcriptase ^[1]

In vitro

In vitro, adefovir is a potent inhibitor of viral replication in human hepatoma cell lines stably transfected with HBV and in primary duck hepatocytes infected with duck HBV (DHBV). Adefovir does not prevent initiation of infection in primary duck hepatocyte cultures. Adefovir is also reported to exhibit immunomodulatory effects, including stimulation of natural killer cell activity and interferon alpha production.

In vivo

Adefovir has a poor oral bioavailability and it is usually used via intraperitoneal injection.

References

[1] Julien Delmas, et al. Antimicrob Agents Chemother. 2002, 46(2): 425-433.

Synonyms

Phosphonic acid, P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-

Phosphonic acid, [[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-

P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid

9-(2-Phosphonylmethoxyethyl)adenine

PMEA

9-[2-(Phosphonomethoxy)ethyl]adenine

GS 0393

Adefovir

((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonicacid

[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid

2-(6-Aminopurin-9-yl)ethoxymethylphosphonic acid

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