[CAS NO. 69-81-8] Carbazochrome

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PRODUCTS SPECIFICATIONS [69-81-8]

Catalog

SLK-S5084

Brand

Selleck

CAS

69-81-8

DESCRIPTION [69-81-8]

Overview

MDL	MFCD00130253
Molecular Weight	236.23
Molecular Formula	C10H12N4O3
SMILES	OC1C=2C(=CC(=O)C(=NNC(N)=O)C2)N(C)C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.2332 mL	21.1658 mL	42.3316 mL
5 mM	0.8466 mL	4.2332 mL	8.4663 mL
10 mM	0.4233 mL	2.1166 mL	4.2332 mL
50 mM	0.0847 mL	0.4233 mL	0.8466 mL

Description

Carbazochrome (Adedolon, Adchnon, Adrenostazin, Cromadrenal, Adona, AC-17) is a hemostatic agent that causes the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound.

In vitro

AC-17 (0.1-1 M) reversed the barrier dysfunction induced by tryptase, thrombin and bradykinin without affecting the endothelial permeability enhanced by Ca2+ ionophores such as ionomycin and A23187 or phorbol 12-myristate 13-acetate. AC-17 reversed the tryptase-induced formation of actin stress fibres and disruption of VE-cadherin in porcine aortic endothelial cells (PAECs).

In vivo

AC-17 is a potent agent that inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media.

References

[1] Sendo T, et al. Eur J Pharmacol. 2002, 450(2):203-8.
[2] Sendo T, et al. Naunyn Schmiedebergs Arch Pharmacol. 2003, 368(3):175-80.

Synonyms

Hydrazinecarboxamide, 2-(1,2,3,6-tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)-

Adrenochrome semicarbazone

5,6-Indolinedione, 3-hydroxy-1-methyl-, 5-semicarbazone

2-(1,2,3,6-Tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)hydrazinecarboxamide

Adrenoxyl

Carbazochrome

Adrenostazin

Adrokson

Adroxon

Sangostazin

3-Hydroxy-1-methyl-5,6-indolindione 5-semicarbazone

Adchnon

Cromadrenal

Adedolon

Adrezon

Sangostasin

Carbazochrom

Cartabes

Adrenochrome monosemicarbazone

Cromosil

NSC 73742

2-(3-Hydroxy-1-methyl-6-oxo-2,3-dihydro-1H-indol-5(6H)-ylidene)hydrazinecarboxamide