[CAS NO. 3687-18-1] Homotaurine
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PRODUCTS SPECIFICATIONS [3687-18-1]
Distributor
Catalog
SLK-S5131
Brand
Selleck
CAS
3687-18-1
DESCRIPTION [3687-18-1]
Overview
| MDL | MFCD00008225 |
|---|---|
| Molecular Weight | 139.17 |
| Molecular Formula | C3H9NO3S |
| SMILES | C(S(=O)(=O)O)CCN |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking . It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.
Targets
| GABA receptor [1] |
In vitro
Homotaurine is a small aminosulfonate compound naturally found in seaweeds. It is a compound with features typical of glycosaminoglycanes (GAGs). Homotaurine has been shown to be able to counteract Aβ fibrillogenesis reducing the toxic effects on neurons. Besides the anti-amyloid action, homotaurine has direct effects also on neuronal activity as a modulator of excitatory neurotransmission, due to its binding affinity for GABAA receptors (GABAARs).
In vivo
In experimental models homotaurine administration induced inhibition of Aβ fibrils formation, reduction of the brain pathologic burden, and formation of physiological LTP.
References
Synonyms
1-Propanesulfonic acid, 3-amino-
3-Amino-1-propanesulfonic acid
3-Aminopropanesulfonic acid
Homotaurine
γ-Aminopropylsulfonic acid
3-Aminopropiosulfonic acid
3-Sulfopropylamine
3-Amino-1-propanesulfonate
NSC 77071
NC 758
Tramiprosate
Alzhemed
3-Azaniumylpropane-1-sulfonate
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