[CAS NO. 1098-97-1] Pyrithioxin

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PRODUCTS SPECIFICATIONS [1098-97-1]

Catalog

SLK-S5141

Brand

Selleck

CAS

1098-97-1

DESCRIPTION [1098-97-1]

Overview

MDL	MFCD00151477
Molecular Weight	368.47
Molecular Formula	C16H20N2O4S2
SMILES	C(SSCC=1C(CO)=C(O)C(C)=NC1)C=2C(CO)=C(O)C(C)=NC2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.7139 mL	13.5696 mL	27.1393 mL
5 mM	0.5428 mL	2.7139 mL	5.4279 mL
10 mM	0.2714 mL	1.3570 mL	2.7139 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL

Description

Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.

In vivo

In old rats, chronic administration of pyritinol increases sensitivity to foot shock and spatial retention. It enhances passive avoidance retention in young and old animals. Acute administration of the drug to young rats reveals a dose-dependent increase in levels of adenosinetriphosphate (ATP) in blood and enhances the age-related decreased utilisation of glucose in various regions of the brain. Chronic treatment with pyritinol elevates the high-affinity uptake of choline in hippocampal and striatal synaptosomes, which is reduced by ageing.

References

[1] Hartmann H, et al. Neuropharmacology. 1993, 32(2):119-25.

Synonyms

4-Pyridinemethanol, 3,3′-[dithiobis(methylene)]bis[5-hydroxy-6-methyl-

4-Pyridinemethanol, 3,3′-(dithiodimethylene)bis[5-hydroxy-6-methyl-

3,3′-[Dithiobis(methylene)]bis[5-hydroxy-6-methyl-4-pyridinemethanol]

Bis-(4-hydroxymethyl-5-hydroxy-6-methyl-3-pyridylmethyl) disulfide

3,3′-(Dithiodimethylene)bis[5-hydroxy-6-methyl-4-pyridinemethanol]

Pyritinol

Bis(2-methyl-3-hydroxy-4-hydroxymethylpyridyl-5-methyl) disulfide

Vitamin B₆ disulfide

Bis[(3-hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl)methyl] disulfide

Dipyridoxolyl disulfide

Pyridoxine-5-disulfide

Epocan

Bis[[5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridyl]methyl] disulfide

Encefabol

Bonifen

Bonol

Pyrithioxin

Pyridoxine disulfide

Piritinol

Pyroxidine-5-disulfide