[CAS NO. 871361-88-5] SC66
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PRODUCTS SPECIFICATIONS [871361-88-5]
Store
Catalog
SLK-S5313
Brand
Selleck
CAS
871361-88-5
DESCRIPTION [871361-88-5]
Overview
| MDL | MFCD05025493 |
|---|---|
| Molecular Weight | 276.33 |
| Molecular Formula | C18H16N2O |
| SMILES | O=C1/C(CCC/C1=C\C2=CC=NC=C2)=C/C3=CC=NC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6189 mL | 18.0943 mL | 36.1886 mL |
| 5 mM | 0.7238 mL | 3.6189 mL | 7.2377 mL |
| 10 mM | 0.3619 mL | 1.8094 mL | 3.6189 mL |
| 50 mM | 0.0724 mL | 0.3619 mL | 0.7238 mL |
Description
SC66 is an allosteric inhibitor which displays a dual-inhibitory function toward activity with IC50 values of 0.77, 2.85 and 0.47 μg/ml in HepG2, Huh7 and Hep3B cells after 72 h treatment, respectively.
Targets
| Akt [1] |
In vitro
SC66 reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in HCC cells. SC66 treatment leads to a reduction in total and phospho-AKT levels. This is associated with alterations in cytoskeleton organization, a reduction in expression levels of E-cadherin, β-catenin and phospho-FAK, together with up-regulation of Snail protein levels. In addition, SC66 induces the production of reactive oxygen species (ROS) and DNA damage. SC66 affects AKT/mTOR signaling in HCC cell lines.
In vivo
In the mouse xenograft tumor model of Hep3B cells, SC66 treatment significantly reduces tumor volume to 37% on day 17 of treatment when compared with tumors in the untreated group. The inhibition of cell growth correlates with a reduction in phospho-AKT levels in the tumors of animals treated with SC66.
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